Evidence map›Paper›PMID 37805125›Full record

ArticleJournal of molecular and cellular cardiology2023

Caveolae-associated cAMP/Ca

Roman Y Medvedev, Daniel G P Turner, Frank C DeGuire, Vladislav Leonov, Di Lang, Julia Gorelik, Francisco J Alvarado, Vladimir E Bondarenko, Alexey V Glukhov

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Downregulation of L-type CaHeart rhythm · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Phosphodiesterases: Evolving Concepts and Implications for Human Therapeutics.Annual review of pharmacology and toxicology · 2025
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Roman Y MedvedevDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Daniel G P TurnerDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Frank C DeGuireDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Vladislav LeonovDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Di LangDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA; Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Julia GorelikNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Francisco J AlvaradoDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Vladimir E BondarenkoDepartment of Mathematics and Statistics, Georgia State University, Atlanta, GA, USA.
Alexey V GlukhovDepartment of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA. Electronic address: aglukhov@medicine.wisc.edu.
University of Wisconsin–Madison · USGeorgia State University · USImperial College London · GBUniversity of California, San Francisco · US

Funding

Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1M
Training Program In Molecular AND Cellular PharmacologyT32GM008688 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 1998 to 2020
$6.0M
Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac RemodelingR01HL141214 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Alexey V Glukhov · 2018 to 2026
$3.8M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
Mechanisms of calcium-induced arrhythmias in arrhythmogenic right ventricular cardiomyopathyR01HL161070 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Francisco J Alvarado · 2022 to 2026
$1.9M
KCNJ2-Induced Arrhythmia Mechanisms in CPVT and Heart Failure.R01HL139738 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI ECKHARDT, LEE LOCHBAUM · 2018 to 2021
$1.5M
Engineered Anisotropic and Vascularized Human Cardiac PatchR01HL146652 · NHLBI · TEXAS ENGINEERING EXPERIMENT STATION · PI ZHAO, FENG · 2020 to 2023
$1.4M
NHLBI NIH HHS R01 HL139738NHLBI NIH HHS R01 HL141214NHLBI NIH HHS R01 HL146652NHLBI NIH HHS R01 HL161070NHLBI NIH HHS R25 HL145817NHLBI NIH HHS T32 HL007444NIGMS NIH HHS T32 GM008688
6 · The paper itself

Abstract

Caveolae are tiny invaginations in the sarcolemma that buffer extra membrane and contribute to mechanical regulation of cellular function. While the role of caveolae in membrane mechanosensation has been studied predominantly in non-cardiomyocyte cells, caveolae contribution to cardiac mechanotransduction remains elusive. Here, we studied the role of caveolae in the regulation of Ca

Indexed as

Atrial FibrillationMyocytes, CardiacAnimalsCaveolaeCyclic AMPMechanotransduction, CellularMiceSignal TransductionCyclic AMPAtrial myocyteCalcium dynamicsCaveolaCyclic adenosine monophosphateProtein kinase ARyanodine receptorStretch

Identifiers

PMID37805125
PMCPMC10842990
OpenAlexW4387363441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.