ArticleCell2023
Generative replay underlies compositional inference in the hippocampal-prefrontal circuit.
Article in Cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Inferential planning in the frontal cortex.Cell reports · 2026Article
- Unveiling the Aha! moment: A computational account of insight in active inference.Psychonomic bulletin & review · 2026Review
- Offline generative network reconfiguration guides insight-like accelerated learning by assimilation into schema in rats.Nature communications · 2026Article
- The compositionality continuum as a principle for studying the neural basis of intelligence.Nature neuroscience · 2026Review
- Mental bootstrapping enables human-level concept learning in self-supervised deep models.Science advances · 2026Article
- Compositional neurosymbolic representations enable efficient active exploration.Nature communications · 2026Article
- Data augmentation as a framework for modeling hippocampal contributions to generalization.ArXiv · 2026Article
- Human curriculum learning of a cue combination task.Nature human behaviour · 2026Article
- An abstract relational map emerges in the human medial prefrontal cortex with consolidation.Current biology : CB · 2026Article
- Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex.Nature neuroscience · 2026Article
- Planning in the Brain: It's Not What You Think It Is.Annual review of neuroscience · 2026Review
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- Spatial amyloid-informed multimodal brain age as an early marker of Alzheimer's-related vulnerability and risk stratification.The journal of prevention of Alzheimer's disease · 2026Article
- Sharp wave-ripple clusters enhance hippocampal-neocortical engagement for memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- Noradrenaline causes a spread of association in the hippocampal cognitive map.Nature communications · 2026Article
- Neural sampling from cognitive maps enables goal-directed imagination and planning.Nature machine intelligence · 2026Article
- The active construction of past episodes.Translational neuroscience · 2026Article
- Neural representation of action symbols in primate frontal cortex.bioRxiv : the preprint server for biology · 2025Article
- Dynamic Synchronization and Resonance as the Origin of 1/f Fluctuations-Amplitude Modulation Across Music and Nature.Entropy (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
Human reasoning depends on reusing pieces of information by putting them together in new ways. However, very little is known about how compositional computation is implemented in the brain. Here, we ask participants to solve a series of problems that each require constructing a whole from a set of elements. With fMRI, we find that representations of novel constructed objects in the frontal cortex and hippocampus are relational and compositional. With MEG, we find that replay assembles elements into compounds, with each replay sequence constituting a hypothesis about a possible configuration of elements. The content of sequences evolves as participants solve each puzzle, progressing from predictable to uncertain elements and gradually converging on the correct configuration. Together, these results suggest a computational bridge between apparently distinct functions of hippocampal-prefrontal circuitry and a role for generative replay in compositional inference and hypothesis testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.