ArticleCurrent biology : CB2023
Lateral orbitofrontal cortex integrates predictive information across multiple cues to guide behavior.
Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Influence of sex and systemic lupus erythematosus disease status on cerebral cortex structure.Lupus science & medicine · 2026Trial
- Identity-specific reward expectations in orbitofrontal cortex guide goal-directed choices.PLoS biology · 2026Article
- Temporal interference stimulation for deep brain neuromodulation in humans.Nature biomedical engineering · 2026Review
- Autism Spectrum Disorder-Associated Genes Enrich in Discrete Cortical, Limbic and Cerebellar Brain Regions.The European journal of neuroscience · 2026Article
- Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus.Behavioral neuroscience · 2026Article
- Twin differences in the Minnesota Trust Game relate to neural mechanisms of suspiciousness.Cognitive, affective & behavioral neuroscience · 2025Article
- Distinct contributions of anterior and posterior orbitofrontal cortex to outcome-guided behavior.bioRxiv : the preprint server for biology · 2025Article
- Article
- The curious case of dopaminergic prediction errors and learning associative information beyond value.Nature reviews. Neuroscience · 2025Review
- The medial and lateral orbitofrontal cortex jointly represent the cognitive map of task space.Communications biology · 2025Article
- Neural basis of reward expectancy inducing proactive aggression.Cognitive, affective & behavioral neuroscience · 2024Article
- Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making.iScience · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Individuals are often faced with multiple cues that concurrently predict the same outcome, and combining these predictions may benefit behavior. Previous work has studied the neural basis of decision-making, predominantly using isolated sensory stimuli, and so the mechanisms that allow us to leverage multiple cues remain unclear. In two experiments, we used neuroimaging and network-targeted brain stimulation to probe how the brain integrates outcome predictions to guide adaptive behavior. We identified neural signatures of outcome integration in the lateral orbitofrontal cortex (OFC), where concurrently presented cues evoke stronger pattern-based representations of expected outcomes. Moreover, perturbing lateral OFC network activity impairs subjects' ability to leverage predictions from multiple cues to facilitate responding. Intriguingly, we found similar behavioral and brain mechanisms for reward-predicting cues and for cues predicting the absence of reward. These findings highlight a causal role for the lateral OFC in utilizing outcome predictions from multiple cues to guide behavior.
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Registered trials
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