ArticleMolecular biology and evolution2023
Horizontally Transferred Salivary Protein Promotes Insect Feeding by Suppressing Ferredoxin-Mediated Plant Defenses.
Article in Molecular biology and evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 25 citations in OpenAlex.
- The salivary protein NlG8 from Nilaparvata lugens induces both direct and indirect resistance in host rice plants.The New phytologist · 2026Article
- Molecular interface of plant-insect warfare: functions and applications of salivary effectors in piercing-sucking pests.Pest management science · 2026Review
- Alternative splicing serves as a molecular strategy for saliva evolution and diversification in an endoparasitoid, Pteromalus puparum.BMC genomics · 2026Article
- A bacterial gene acquired by parasitoid wasps contributes to venom secretion against host defence.The EMBO journal · 2026Article
- New potential antimicrobial peptides with mirror-symmetrical structure in fungi and insects.Frontiers in microbiology · 2026Article
- Overexpression of the Dicer family genes influences lifespan and stress resistance in a tissue-, sex-, and stressor-specific manner in Drosophila melanogaster.Biogerontology · 2025Article
- Functional Divergence of Plant-Derived Thaumatin-Like Protein Genes in Two Closely Related Whitefly Species.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Functional Carbohydrate-Active Enzymes Acquired by Horizontal Gene Transfer from Plants in the Whitefly Bemisia tabaci.Genome biology and evolution · 2025Article
- Protein Dynamics in Plant Immunity: Insights into Plant-Pest Interactions.International journal of molecular sciences · 2024Review
- Salivary Protein Cyclin-Dependent Kinase-like from Grain AphidInternational journal of molecular sciences · 2024Article
- Roles of herbivorous insects salivary proteins.Heliyon · 2024Review
- A pipeline contributes to efficient identification of salivary proteins in short-headed planthopper, Epeurysa nawaii.Scientific reports · 2024Article
- Salivary proteins potentially derived from horizontal gene transfer are critical for salivary sheath formation and other feeding processes.Communications biology · 2024Article
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herbivorous insects such as whiteflies, planthoppers, and aphids secrete abundant orphan proteins to facilitate feeding. Yet, how these genes are recruited and evolve to mediate plant-insect interaction remains unknown. In this study, we report a horizontal gene transfer (HGT) event from fungi to an ancestor of Aleyrodidae insects approximately 42 to 190 million years ago. BtFTSP1 is a salivary protein that is secreted into host plants during Bemisia tabaci feeding. It targets a defensive ferredoxin 1 in Nicotiana tabacum (NtFD1) and disrupts the NtFD1-NtFD1 interaction in plant cytosol, leading to the degradation of NtFD1 in a ubiquitin-dependent manner. Silencing BtFTSP1 has negative effects on B. tabaci feeding while overexpressing BtFTSP1 in N. tabacum benefits insects and rescues the adverse effect caused by NtFD1 overexpression. The association between BtFTSP1 and NtFD1 is newly evolved after HGT, with the homologous FTSP in its fungal donor failing to interact and destabilize NtFD1. Our study illustrates the important roles of horizontally transferred genes in plant-insect interactions and suggests the potential origin of orphan salivary genes.
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