ArticleThe international journal of cardiovascular imaging2023
Association of LDL-C level with neoatherosclerosis and plaque vulnerability in patients with late restenosis: an optical coherence tomography study.
Article in The international journal of cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Acute Myocardial Infarction from Stent Thrombosis Following a Loss to Follow-up Triggered by Financial Barriers to PCSK9 Inhibitor Therapy.Internal medicine (Tokyo, Japan) · 2026Article
- Neovascularization restructuring patterns in diabetic patients with coronary in stent restenosis: an in-vivo optical coherence tomography study.The international journal of cardiovascular imaging · 2025Article
- Predictive Utility of PLR and Platelet-to-LDL Ratio for in-Stent Restenosis Following Carotid Artery Stenting.Vascular health and risk management · 2025Article
- Impact of acute coronary syndrome on early in-stent neoatherosclerosis as shown by optical coherence tomography.AsiaIntervention · 2024Article
- Neoatherosclerosis: A Distinctive Pathological Mechanism of Stent Failure.Reviews in cardiovascular medicine · 2024Review
- Low-density Lipoprotein Cholesterol Level on Admission and After One Year with Clinical Outcomes in Patients Admitted with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention.Heart views : the official journal of the Gulf Heart AssociationArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Neoatherosclerosis (NA) is a significant contributor to late stent failure; however, predictors of late in-stent restenosis (ISR) with NA have not been systematically reported. This study aimed to identify predictors of NA incidence and plaque vulnerability in patients with late ISR and the role of low-density lipoprotein cholesterol (LDL-C) levels in this process. A total of 216 patients with 216 lesions who underwent optical coherence tomography (OCT) before interventional procedure for late drug-eluting stent ISR were enrolled and divided into NA and non-NA groups based on OCT findings. Results showed that higher LDL-C levels were associated with NA, thin-cap fibroatheroma (TCFA), intimal disruption, plaque erosion, and thrombosis. Multivariate regression analysis revealed that the LDL-C level was an independent risk factor for NA and TCFA. The LDL-C levels exhibited a significant predictive value for NA and TCFA, surpassing other factors such as stent age and other lipid types. In conclusion, a high LDL-C level is an independent predictor of NA incidence and plaque vulnerability in patients with late ISR.
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Registered trials
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