Evidence map›Paper›PMID 37804385›Full record

ArticleVeterinary research communications2024

Enferplex bovine TB antibody test and bovine TB diagnosis: letter to the editor.

Neil Watt, Alastair Hayton, Keith Cutler, Amanda O'Brien, John Clarke, Gordon D Harkiss

Open access · hybridAbstract readLetter
In one paragraph

Article in Veterinary research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Neil WattMV Diagnostics Ltd, Roslin Innovation Centre, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.
Alastair HaytonSureFarm Ltd, The Transmission Hall, Rampisham Business Centre, Rampisham Down, Maiden Newton, Dorset, DT2 0HS, UK.
Keith CutlerSureFarm Ltd, The Transmission Hall, Rampisham Business Centre, Rampisham Down, Maiden Newton, Dorset, DT2 0HS, UK.
Amanda O'BrienEnfer Scientific ULC, M7 Business Park, Newhall, Naas, Co., Kildare, W91 FD74, Ireland.
John ClarkeEnfer Scientific ULC, M7 Business Park, Newhall, Naas, Co., Kildare, W91 FD74, Ireland.
Gordon D HarkissMV Diagnostics Ltd, Roslin Innovation Centre, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK. info@mvdiagnostics.co.uk.
Bord na Móna (Ireland) · IERoslin Cells (United Kingdom) · GBRoslin Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine tuberculosis is usually diagnosed using tuberculin skin and interferon gamma tests. However, it is clear these tests miss infected animals due to poor sensitivity. The Enferplex Bovine TB antibody test has been validated by the World Organisation for Animal Health as fit for purpose in diagnosing bovine TB. A recent paper by Madden and colleagues (Veterinary Research Communications published online 17 August 2023) presented data on the future risk of Enferplex test antibody positive animals developing bovine TB. We argue in this communication that this does not make sense. Also, the study design did not include measuring antibodies at the point of censure of the animals and hence the survival analysis performed was meaningless. Most significantly, the study misses the point that skin and interferon gamma tests fail to detect a significant proportion of infected animals identified by the Enferplex test.

Indexed as

Cattle DiseasesTuberculosis, BovineAnimalsCattleInterferon-gammaSensitivity and SpecificityTuberculin TestInterferon-gammaAntibodiesBovineDiagnosisInterferonTuberculinTuberculosis

Identifiers

PMID37804385
PMCPMC10810908
OpenAlexW4387428779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.