ArticleJACC. Heart failure2023
Maternal and Pregnancy Outcomes Following Heart Transplantation in the United States.
Article in JACC. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Adverse Pregnancy Outcomes in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study.BMC medicine · 2026Observational
- Sex Differences in Heart Transplantation: Evolving Trends and Insights.Current cardiology reports · 2025Review
- Severe maternal morbidity and risk of transplant rejection in pregnant patients with a history of solid-organ transplant.American journal of obstetrics & gynecology MFM · 2025Article
- Maternal heart failure: state-of-the-art review.Heart failure reviews · 2025Review
- Patient Perceptions and Knowledge Surrounding Pregnancy After Heart Transplantation: A Multicenter Study.Circulation. Heart failure · 2024Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundImproved survival following heart transplantation (HT) has led to more recipients contemplating pregnancy, but data on outcomes are limited.
objectivesThe authors used a national data set to investigate and describe outcomes of pregnancies and deliveries in the United States in HT recipients.
methodsDiagnosis and procedure codes from the 2010-2020 Nationwide Readmissions Database identified delivery hospitalizations, history of HT, comorbid conditions, and outcomes. The authors compared rates of severe maternal morbidity (SMM), nontransfusion SMM, cardiovascular SMM (cSMM), and preterm birth from delivery hospitalization between HT recipients and no-HT recipients. The authors evaluated readmission to 330 days postpartum. Logistic and proportional hazard regressions were performed, adjusting for age, socioeconomic and facility characteristics, and clinical comorbidities.
resultsAmong 19,399,521 deliveries, 105 were HT recipients. Compared with no-HT, HT recipients were at higher risk for all SMM (24.8% vs 1.7%), nontransfusion SMM (20.8% vs 0.7%), cSMM (7.3% vs 0.12%), and preterm birth (43.3% vs 8.2%), all P < 0.001. In adjusted analyses, HT recipients had 16-fold greater odds of SMM, 28-fold greater odds of nontransfusion SMM, 38-fold greater odds of cSMM, and 7-fold greater odds of preterm birth. HT recipients had higher morbidity rates during delivery hospitalization and higher readmission rates within 1 year following delivery (26.9% vs 3.8%; adjusted HR: 6.03 [95% CI: 3.73-9.75]).
conclusionsDelivery with history of HT is associated with significantly increased rates of SMM, preterm birth, and hospital readmission. These results provide data regarding pregnancy outcomes for use when counseling patients with HT history who are considering pregnancy or who are pregnant.
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