Evidence map›Paper›PMID 37804211›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2024

Focused ultrasound as an alternative to dry needling for the treatment of tendinopathies: A murine model.

Sujata Khandare, Molly Smallcomb, Jacob Elliott, Meghan E Vidt, Julianna C Simon

Open access · hybridAbstract read
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 82% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Application of Focused Ultrasound for the Treatment of Tendinopathy: An In Vivo Feasibility, Safety, and Efficacy Study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sujata KhandareBiomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-5003-4044
Molly SmallcombGraduate Program in Acoustics, Pennsylvania State University, University Park, Pennsylvania, USA.
Jacob ElliottGraduate Program in Acoustics, Pennsylvania State University, University Park, Pennsylvania, USA.
Meghan E VidtBiomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-8811-8569
Julianna C SimonBiomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.
Pennsylvania State University · US

Funding

Histotripsy for collagenous tissues: a novel therapeutic approach to tendon injuryR21EB027886 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI SIMON, JULIANNA, VIDT, MEGHAN ELISE · 2019 to 2021
$574k
NIBIB NIH HHS R21 EB027886NIBIB NIH HHS R21EB027886
6 · The paper itself

Abstract

Tendinopathies account for 30% of 102 million annual musculoskeletal injuries occurring annually in the United States. Current treatments, like dry needling, induce microdamage to promote healing but produce mixed success rates. Previously, we showed focused ultrasound can noninvasively create microdamage while preserving mechanical properties in ex vivo murine tendons. This present study compared growth factor, histological, and mechanical effects after focused ultrasound or dry needling treatments in an in vivo murine tendon injury model. Partial Achilles tenotomy was performed in 26 rats. One-week postsurgery, tendons were treated with focused ultrasound (1.5 MHz, 1-ms pulses at 10 Hz for 106 s, p

Indexed as

Achilles TendonTendinopathyAnimalsDisease Models, AnimalMicePercutaneous Collagen InductionRatsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Adry needling (DN)focused ultrasound (fUS)growth factorshistologymechanical testing

Identifiers

PMID37804211
PMCPMC10932869
OpenAlexW4387424905

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.