ArticleJournal of the American Heart Association2023
Association Between Whole Blood-Derived Mitochondrial DNA Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk.
Open access · goldAbstract read
In one paragraph
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Cardiovascular-kidney-metabolic syndrome as a mitochondrial systems disorder.Nature reviews. Nephrology · 2026Review
- Article
- Mitochondrial-Endothelial Crosstalk in Cardiometabolic Disease: Mechanisms and Translational Opportunities in the Multi-omics Era.Reviews in cardiovascular medicine · 2026Review
- Association of Mitochondrial DNA Levels in Peripheral Blood Leukocytes With Physical Performance in Older Adults.Geriatrics & gerontology international · 2026Article
- Association of leukocyte mitochondrial DNA copy number and inflammation with mortality among older adults.Communications medicine · 2026Article
- The role of vascular aging, bone marrow and immune system in hypertension.Cell death discovery · 2026Review
- Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases.Aging cell · 2025Article
- Mitochondrial Genome Variants and Nuclear Mitochondrial DNA Segments in 7331 Individuals from NyuWa and 1KGP.Genomics, proteomics & bioinformatics · 2025Article
- Review
- Circulating mitochondrial DNA signature in cardiometabolic patients.Cardiovascular diabetology · 2025Article
- Mitochondrial DNA in atherosclerosis research progress: a mini review.Frontiers in immunology · 2025Review
- Implications of mtDNA in human health and diseases.Biotechnologia · 2025Review
- Mitochondrial DNA damage in HIV infection: a mechanistic driver of immunometabolic dysfunction and chronic inflammation.Frontiers in immunology · 2025Review
- Leukocyte mitochondrial DNA copy number and cardiovascular disease: A systematic review and meta-analysis of cohort studies.iScience · 2024Article
- The Role of Mitochondrial Copy Number in Neurodegenerative Diseases: Present Insights and Future Directions.International journal of molecular sciences · 2024Review
- Mitochondrial related variants associated with cardiovascular traits.Frontiers in physiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 17 institutions in 2 countries.
Xue LiuDepartment of Biostatistics, School of Public Health Boston University Boston MA USA.ORCID 0000-0002-4196-3597
Xianbang SunDepartment of Biostatistics, School of Public Health Boston University Boston MA USA.
Yuankai ZhangDepartment of Biostatistics, School of Public Health Boston University Boston MA USA.
Wenqing JiangDepartment of Biostatistics, School of Public Health Boston University Boston MA USA.
Meng LaiDepartment of Biostatistics, School of Public Health Boston University Boston MA USA.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USA.ORCID 0000-0003-2749-1279
Laura M RaffieldDepartment of Genetics University of North Carolina at Chapel Hill Chapel Hill NC USA.ORCID 0000-0002-7892-193X
Lawrence F BielakDepartment of Epidemiology, School of Public Health University of Michigan Ann Arbor MI USA.ORCID 0000-0002-3443-8030
Wei ZhaoDepartment of Epidemiology, School of Public Health University of Michigan Ann Arbor MI USA.ORCID 0000-0001-7388-0692
Achilleas PitsillidesDepartment of Biostatistics, School of Public Health Boston University Boston MA USA.ORCID 0000-0002-2658-1566
Jeffrey HaesslerFred Hutchinson Cancer Center, Division of Public Health Science Seattle WA USA.
Yinan ZhengFeinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0002-2006-7320
Thomas W BlackwellTOPMed Informatics Research Center University of Michigan Ann Arbor MI USA.
Jie YaoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance CA USA.ORCID 0000-0002-8822-0651
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance CA USA.ORCID 0000-0002-5264-5068
Yong QianLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health Baltimore MD USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology University of Minnesota Minneapolis MN USA.ORCID 0000-0001-6968-6985
Nathan PankratzDepartment of Computational Pathology University of Minnesota Minneapolis MN USA.ORCID 0000-0001-5958-693X
Stephen S RichCenter for Public Health Genomics University of Virginia Charlottesville VA USA.ORCID 0000-0003-3872-7793
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance CA USA.ORCID 0000-0002-2756-4370
Patricia A PeyserDepartment of Epidemiology, School of Public Health University of Michigan Ann Arbor MI USA.ORCID 0000-0002-9717-8459
Susan R HeckbertCardiovascular Health Research Unit and Department of Epidemiology University of Washington Seattle WA USA.ORCID 0000-0002-7100-512X
Sudha SeshadriGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases University of Texas Health Science Center at San Antonio San Antonio TX USA.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences The University of Texas Health Science Center at Houston Houston TX USA.ORCID 0000-0001-8813-0544
Megan L GroveHuman Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences The University of Texas Health Science Center at Houston Houston TX USA.
Nicholas B LarsonDivision of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic College of Medicine and Science Rochester MN USA.ORCID 0000-0002-3468-4215
Jennifer A SmithDepartment of Epidemiology, School of Public Health University of Michigan Ann Arbor MI USA.ORCID 0000-0002-3575-5468
Ramachandran S VasanFramingham Heart Study, National Heart, Lung, and Blood Institute Framingham MA USA.ORCID 0000-0001-7357-5970
Annette L FitzpatrickDepartments of Family Medicine, Epidemiology, and Global Health University of Washington Seattle WA USA.
Myriam FornageCenter for Human Genetics University of Texas Health Science Center at Houston Houston TX USA.ORCID 0000-0003-0677-8158
Jun DingLongitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health Baltimore MD USA.
April P CarsonDepartment of Medicine University of Mississippi Medical Center Jackson MS USA.ORCID 0000-0002-7970-6756
Goncalo AbecasisTOPMed Informatics Research Center University of Michigan Ann Arbor MI USA.
Josée DupuisDepartment of Biostatistics, School of Public Health Boston University Boston MA USA.ORCID 0000-0003-2871-3603
Alexander ReinerFred Hutchinson Cancer Center, Division of Public Health Science Seattle WA USA.ORCID 0000-0002-1427-4470
Charles KooperbergFred Hutchinson Cancer Center, Division of Public Health Science Seattle WA USA.
Lifang HouFeinberg School of Medicine Northwestern University Chicago IL USA.ORCID 0000-0003-4877-0031
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USA.ORCID 0000-0002-7278-2190
James G WilsonDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center Boston MA USA.
Daniel LevyFramingham Heart Study, National Heart, Lung, and Blood Institute Framingham MA USA.ORCID 0000-0003-1843-8724
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance CA USA.ORCID 0000-0001-7191-1723
Joshua C BisCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USA.ORCID 0000-0002-3409-1110
TOPMed mtDNA Working Group in NHLBI Trans‐Omics for Precision Medicine (TOPMed) Consortium
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases University of Texas Health Science Center at San Antonio San Antonio TX USA.ORCID 0000-0002-1115-4430
Dan E ArkingMcKusick-Nathans Institute Department of Genetic Medicine Johns Hopkins University School of Medicine MD Baltimore USA.ORCID 0000-0001-8980-8695
Chunyu LiuDepartment of Biostatistics, School of Public Health Boston University Boston MA USA.ORCID 0000-0002-9160-0153
Boston University · USUniversity of Michigan · USUniversity of Washington · USUCLA Medical Center · USFred Hutch Cancer Center · USNational Institutes of Health · USNorthwestern University · USUniversity of Minnesota · USBaylor College of Medicine · USBeth Israel Deaconess Medical Center · USCenter for Human Genetics · USJackson Memorial Hospital · USJohns Hopkins University · USMayo Clinic · USThe University of Texas Health Science Center at Houston · USUniversity of North Carolina at Chapel Hill · USUniversity of Virginia · US
Funding
Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6MThe Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MTHE FRAMINGHAM HEART STUDYN01HC25195 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAMACHANDRAN, VASAN S · 2007 to 2014
$83.8MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MWOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MHYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1MNCATS NIH HHS KL2 TR002490NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NHGRI NIH HHS U54 HG003067NHGRI NIH HHS U54 HG003273NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS 75N92022D00001NHLBI NIH HHS 75N92022D00002NHLBI NIH HHS 75N92022D00003NHLBI NIH HHS 75N92022D00004NHLBI NIH HHS 75N92022D00005NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201000031CNHLBI NIH HHS HHSN268201100037CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201500014CNHLBI NIH HHS HHSN268201500015CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01HC25195NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL141292NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NHLBI NIH HHS U10 HL054457NHLBI NIH HHS U10 HL054464NHLBI NIH HHS U10 HL054481NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG059727NIDDK NIH HHS P30 DK063491NIEHS NIH HHS HHSN268201600033CNIMHD NIH HHS HHSN268201800013IWHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
Abstract
Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia).
Indexed as
Cardiovascular DiseasesCoronary DiseaseDiabetes MellitusHypertensionCholesterol, HDLCholesterol, LDLCross-Sectional StudiesDNA Copy Number VariationsDNA, MitochondrialHumansObesityRisk FactorsCholesterol, HDLCholesterol, LDLDNA, Mitochondrialcardiometabolic risk factorscardiovascular diseaselow‐density lipoprotein cholesterolMendelian randomizationmitochondrial DNA copy numbervascular atherosclerosis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.