ArticleThe Journal of clinical endocrinology and metabolism2024
The Vitamin D Metabolite Ratio Is Associated With Volumetric Bone Density in Older Men.
Charles Ginsberg, Terri Blackwell, Jonathan H Cheng, O Alison Potok, Jane A Cauley, Kristine E Ensrud, Simon Hsu, Deborah M Kado, Eric Orwoll, Peggy M Cawthon and 1 more
Article in The Journal of clinical endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors at 7 institutions in 1 country.
Charles GinsbergDivision of Nephrology-Hypertension, University of California, San Diego, CA 92037, USA.ORCID 0000-0001-9408-3684
Terri BlackwellCalifornia Pacific Medical Center Research Institute, Department of Epidemiology, University of California, SanFrancisco, San Francisco, CA 94107, USA.
Jonathan H ChengDivision of Nephrology-Hypertension, University of California, San Diego, CA 92037, USA.
O Alison PotokDivision of Nephrology-Hypertension, University of California, San Diego, CA 92037, USA.
Jane A CauleyDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Kristine E EnsrudDepartment of Medicine and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA.
Simon HsuDivision of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0003-3780-294X
Deborah M KadoDepartment of Medicine, Stanford University, Palo Alto, CA 94304, USA.
Eric OrwollDivision of Endocrinology, Metabolism and Clinical Nutrition, Department of Medicine, Oregon Health and Sciences University, Portland, OR 97239, USA.ORCID 0000-0002-8520-7355
Peggy M CawthonCalifornia Pacific Medical Center Research Institute, Department of Epidemiology, University of California, SanFrancisco, San Francisco, CA 94107, USA.
Joachim H IxDivision of Nephrology-Hypertension, University of California, San Diego, CA 92037, USA.
University of California San Diego · USUniversity of California, San Francisco · USOregon Health & Science University · USStanford University · USUniversity of Minnesota · USUniversity of Pittsburgh · USUniversity of Washington · US
Funding
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Long term fracture risk and change in peripheral bone in the oldest old men: The MrOS studyR01AG066671 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI BOUXSEIN, MARY L, CAWTHON, PEGGY MANNEN · 2020 to 2024
$13.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
Influence of Vitamin D Binding Protein on Clinical Measures of Vitamin D Status and Bone HealthK23DK118197 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GINSBERG, CHARLES · 2018 to 2022
$1.0M
The Clinical Applications of the Difference in Estimated Glomerular Filtration Rate by Cystatin C vs. Creatinine (eGFRDiff)K23DK128604 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI POTOK, OLIVIA ALISON · 2021 to 2025
$951k
Mentored Patient Oriented Research in Kidney DiseaseK24DK110427 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IX, JOACHIM H · 2016 to 2020
contextSerum 25-hydroxyvitamin D (25(OH)D) is the current marker of vitamin D adequacy, but its relationship with bone health has been inconsistent. The ratio of 24,25-dihydroxyvitamin D3 to 25(OH)D3 (vitamin D metabolite ratio or VMR) is a marker of vitamin D that has been associated with longitudinal changes in bone mineral density (BMD) and fracture risk.
objectiveHigh-resolution peripheral quantitative computed tomography (HR-pQCT) provides information on bone health beyond standard dual-energy x-ray absorptiometry, in that it measures volumetric BMD (vBMD) as well bone strength. The relationship of the VMR with vBMD and bone strength remains unknown.
methodsWe evaluated the associations of the VMR and 25(OH)D3 with vBMD and bone strength in the distal radius and tibia, assessed by HR-pQCT in 545 older men participating in the Osteoporotic Fractures in Men (MrOS) Study. Primary outcomes were vBMD and estimated failure load (EFL, a marker of bone strength) at the distal radius and tibia.
resultsThe mean age was 84 ± 4 years, 88.3% were White, and 32% had an estimated glomerular filtration rate <60 mL/min/1.73 m2. In adjusted models, each twofold higher VMR was associated with a 9% (3%, 16%) higher total vBMD and a 13% (5%, 21%) higher EFL at the distal radius. Results were similar at the distal tibia. 25(OH)D3 concentrations were not associated with any of the studied outcomes.
conclusionAmong older men, a higher VMR was associated with greater vBMD and bone strength while 25(OH)D3 was not. The VMR may serve as a valuable marker of skeletal health in older men.
Indexed as
Bone DensityFractures, BoneAbsorptiometry, PhotonAgedAged, 80 and overCalcifediolHumansMaleRadiusTibiaVitamin DVitaminsCalcifediolVitamin DVitaminsDXAfracture preventionHR-pQCTvit osteoporosis
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The Vitamin D Metabolite Ratio Is Associated With Volumetric Bone Density in Older Men. · full record | OpenQuestion