ArticleThe Plant cell2024
The serine-glycine-one-carbon metabolic network orchestrates changes in nitrogen and sulfur metabolism and shapes plant development.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Photorespiration Is Associated with Nitrogen Metabolism and Nitrogen Productivity in Kentucky Bluegrass.Biology · 2026Article
- Increased pine root exudation of phenolic acids and amino acids under drought.Tree physiology · 2026Article
- Shaping kale morphology and physiology using precision LED light recipes.Journal of experimental botany · 2026Article
- NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sulfate starvation response modules connect sulfur metabolism to photorespiration and photosynthesis.The Plant journal : for cell and molecular biology · 2026Article
- PERSPECTIVE: organelle positioning as a principle of metabolic regulation and stress tolerance.The Plant journal : for cell and molecular biology · 2026Review
- Article
- Photorespiration is linked to DNA methylation by formate as a one-carbon source.Nature plants · 2026Article
- High sulfate exacerbates heavy metal toxicity in Chinese cabbage (Brassica chinensis L.) by impairing plant ROS scavenging in heavy metals contaminated soil.BMC plant biology · 2026Article
- Multi-omics analysis to uncover constitutive priming and dynamic metabolic reprogramming conferring white rust resistance inFrontiers in plant science · 2026Article
- Foliar folic acid application enhances nitrogen assimilation and improves quality-related metabolites accumulation inFrontiers in plant science · 2026Article
- Evolutionary and functional relationships between plant and microbial CThe New phytologist · 2025Review
- Transcriptional landscape of Atractylodes chinensis contracting root rot.BMC plant biology · 2025Article
- Integrated Transcriptomic and Metabolomic Analyses Shed Light on the Regulation of Aromatic Amino Acid Biosynthesis in a Novel Albino Tea (Current issues in molecular biology · 2025Article
- Phosphoglycerate dehydrogenase is required for kernel development and defines a predominant serine synthesis pathway in maize.The Plant cell · 2025Article
- Guard cell-specific glycine decarboxylase manipulation affects Arabidopsis photosynthesis, growth and stomatal behavior.The New phytologist · 2025Article
- A cytosolic glyoxylate shunt complements the canonical photorespiratory pathway in Arabidopsis.Nature communications · 2025Article
- Non-canonical plant metabolism.Nature plants · 2025Review
- Remodelled ribosomal populations synthesize a specific proteome in proliferating plant tissue during cold.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Metabolic engineering of the serine/glycine network as a means to improve the nitrogen content of crops.Plant biotechnology journal · 2025Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
L-serine (Ser) and L-glycine (Gly) are critically important for the overall functioning of primary metabolism. We investigated the interaction of the phosphorylated pathway of Ser biosynthesis (PPSB) with the photorespiration-associated glycolate pathway of Ser biosynthesis (GPSB) using Arabidopsis thaliana PPSB-deficient lines, GPSB-deficient mutants, and crosses of PPSB with GPSB mutants. PPSB-deficient lines mainly showed retarded primary root growth. Mutation of the photorespiratory enzyme Ser-hydroxymethyltransferase 1 (SHMT1) in a PPSB-deficient background resumed primary root growth and induced a change in the plant metabolic pattern between roots and shoots. Grafting experiments demonstrated that metabolic changes in shoots were responsible for the changes in double mutant development. PPSB disruption led to a reduction in nitrogen (N) and sulfur (S) contents in shoots and a general transcriptional response to nutrient deficiency. Disruption of SHMT1 boosted the Gly flux out of the photorespiratory cycle, which increased the levels of the one-carbon (1C) metabolite 5,10-methylene-tetrahydrofolate and S-adenosylmethionine. Furthermore, disrupting SHMT1 reverted the transcriptional response to N and S deprivation and increased N and S contents in shoots of PPSB-deficient lines. Our work provides genetic evidence of the biological relevance of the Ser-Gly-1C metabolic network in N and S metabolism and in interorgan metabolic homeostasis.
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