Evidence map›Paper›PMID 37803465›Full record

ArticleJournal of neuroinflammation2023

Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease-like neuroinflammation triggered by periodontal disease.

Chuanjiang Zhao, Ryutaro Kuraji, Changchang Ye, Li Gao, Allan Radaic, Pachiyappan Kamarajan, Yoshimasa Taketani, Yvonne L Kapila

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Oral virome in health and disease.Journal of the American Dental Association (1939) · 2026
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  17. Oral microbiota and central nervous system diseases: A review.Neuroprotection (Chichester, England) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Chuanjiang ZhaoDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA.
Ryutaro KurajiDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA.ORCID https://orcid.org/0000-0002-7900-3604
Changchang YeDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA.
Li GaoDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA.
Allan RadaicDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA.ORCID https://orcid.org/0000-0002-0899-9061
Pachiyappan KamarajanDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA.
Yoshimasa TaketaniDepartment of Biosystems and Function and Periodontics, School of Dentistry, University of California Los Angeles, Los Angeles, CA, 90024, USA.
Yvonne L KapilaDepartment of Orofacial Sciences, School of Dentistry, University of California San Francisco, San Francisco, CA, 94143, USA. ykapila@dentistry.ucla.edu.
University of California, Los Angeles · USSun Yat-sen University · CNUniversity of California, San Francisco · US

Funding

Treponema - Host Cell and Tissue InteractionsR01DE025225 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI J CHRISTOPHER FENNO, Yvonne L Kapila · 2015 to 2026
$6.3M
NIDCR NIH HHS R01 DE025225
6 · The paper itself

Abstract

introductionPeriodontitis-related oral microbial dysbiosis is thought to contribute to Alzheimer's disease (AD) neuroinflammation and brain amyloid production. Since probiotics can modulate periodontitis/oral dysbiosis, this study examined the effects of a probiotic/lantibiotic, nisin, in modulating brain pathology triggered by periodontitis.

methodsA polymicrobial mouse model of periodontal disease was used to evaluate the effects of this disease on brain microbiome dysbiosis, neuroinflammation, Alzheimer's-related changes, and nisin's therapeutic potential in this context.

results16S sequencing and real-time PCR data revealed that Nisin treatment mitigated the changes in the brain microbiome composition, diversity, and community structure, and reduced the levels of periodontal pathogen DNA in the brain induced by periodontal disease. Nisin treatment significantly decreased the mRNA expression of pro-inflammatory cytokines (Interleukin-1β/IL-1 β, Interleukin 6/IL-6, and Tumor Necrosis Factor α/TNF-α) in the brain that were elevated by periodontal infection. In addition, the concentrations of amyloid-β 42 (Aβ42), total Tau, and Tau (pS199) (445.69 ± 120.03, 1420.85 ± 331.40, 137.20 ± 36.01) were significantly higher in the infection group compared to the control group (193.01 ± 31.82, 384.27 ± 363.93, 6.09 ± 10.85), respectively. Nisin treatment markedly reduced the Aβ42 (261.80 ± 52.50), total Tau (865.37 ± 304.93), and phosphorylated Tau (82.53 ± 15.77) deposition in the brain of the infection group. DISCUSSION: Nisin abrogation of brain microbiome dysbiosis induces beneficial effects on AD-like pathogenic changes and neuroinflammation, and thereby may serve as a potential therapeutic for periodontal-dysbiosis-related AD.

Indexed as

Alzheimer DiseaseBacteriocinsMicrobiotaNisinPeriodontitisProbioticsAmyloid beta-PeptidesAnimalsBrainDysbiosisInterleukin-6MiceNeuroinflammatory DiseasesAmyloid beta-PeptidesBacteriocinsInterleukin-6Nisinnisin AAntimicrobial therapyBrain microbiomeNeuroinflammationNisinOral microbiomePeriodontal disease

Identifiers

PMID37803465
PMCPMC10557354
OpenAlexW4387407488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.