ArticleBMC complementary medicine and therapies2023
HPLC-ESI/MS-MS characterization of compounds in Dolomiaea costus extract and evaluation of cytotoxic and antiviral properties: molecular mechanisms underlying apoptosis-inducing effect on breast cancer.
Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
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- UPLC-ESI/MS-MS-based phytochemical analysis of Schinopsis balansae leaf extract and anti-skin ageing properties supported with in silico molecular docking experiments.Scientific reports · 2026Article
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- Cavitation-driven extraction: how ultrasound-induced acoustic cavitation maximizes bioactive compound recovery from S. costus roots.Ultrasonics sonochemistry · 2025Article
- Chemical profile of essential oil from Pimenta racemosa leaves, antioxidant potential, and its enzyme inhibitory properties.Scientific reports · 2025Article
- Phytochemicals in Cancer Therapy: A Structured Review of Mechanisms, Challenges, and Progress in Personalized Treatment.Chemistry & biodiversity · 2025Review
- Is sacred animal (Asian Elephant) can be a medicinal repository: a new approach for colon cancer treatment using the methanolic extracts of the dung samples and their valuation for antimicrobial, cytotoxic, and apoptotic actions.BMC complementary medicine and therapies · 2025Article
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- Comparative metabolic profiling of Cordia myxa leaves and fruits based on UPLC-ESI/MS-MS analysis and investigation of antioxidant activities and enzyme inhibitory properties.Scientific reports · 2025Article
- Comprehensive GC-MS Profiling and Multi-Modal Pharmacological Evaluations ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Phenolic amides (avenanthramides) in oats - an update review.Bioengineered · 2024Review
- Small Steps to the Big Picture for Health-Promoting Applications Through the Use of Chickweed (Food science & nutrition · 2024Article
- Current and potential future biological uses ofHeliyon · 2024Review
- Carbon nanotubes: a novel innovation as food supplements and biosensing for food safety.Frontiers in nutrition · 2024Review
- Assessing the cytotoxicity of phenolic and terpene fractions extracted from IraqiF1000Research · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDolomiaea costus (syn: Saussurea costus; Family Asteraceae) occupies an important place in the traditional Chinese medicinal plants and is prescribed for a wide range of disorders. The current study aimed to tentatively identify the phytoconstituents of D. costus extract and to explore antiproliferative activity against human breast cancer cells and its possible apoptotic mechanism along with antiviral activity against human adenovirus 5 (Adv-5).
methodsThe phytoconstituents of 70% ethanol extract of D. costus were assessed using HPLC/ESI-MS/MS technique. The cell viability was investigated against breast cancer cell line (MCF-7) via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Mechanistically, the apoptotic effects on the Bax, Bcl2 and Caspase 3 were determined via quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR). Further, the antiviral activity was assessed against Adv-5 based on virucidal and adsorption mechanisms.
resultsThe HPLC/MS analysis of the extract revealed tentative identification of twenty compounds of polyphenolic nature, mainly flavonoids, lignans, coumarins, and anthocyanidins. The plant extract showed a cytotoxic effect against MCF-7 and Vero cells with IC
conclusionsSuch observations against human breast cancer and viral replication supported further studies for nanoformulations in drug delivery systems as targeting therapy and in vivo studies before biomedical applications.
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