Evidence map›Paper›PMID 37803381›Full record

SynthesisMalaria journal2023

Increasing prevalence of malaria and acute dengue virus coinfection in Africa: a meta-analysis and meta-regression of cross-sectional studies.

Tewelde T Gebremariam, Henk D F H Schallig, Zeleke M Kurmane, Jonas B Danquah

Erratum issuedAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Malaria journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Tropical medicine and infectious disease · 2026
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  12. Diversity ofInsects · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Tewelde T GebremariamSchool of Graduate Studies and Research, Frantz Fanon University, Hargeisa, Somaliland. ttesfayg@gmail.com.
Henk D F H SchalligDepartment of Medical Microbiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Zeleke M KurmaneSchool of Medical Laboratory, Institute of Health, Jimma University, Jimma, Ethiopia.
Jonas B DanquahAnimal Research Institute, Animal Health Division, Accra, Ghana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMalaria and dengue fever are the leading causes of acute, undifferentiated febrile illness. In Africa, misdiagnosis of dengue fever as malaria is a common scenario. Through a systematic review of the published literature, this study seeks to estimate the prevalence of dengue and malaria coinfection among acute undifferentiated febrile diseases in Africa.

methodsRelevant publications were systematically searched in the PubMed, Cochrane Library, and Google Scholar until May 19, 2023. A random-effects meta-analysis and meta-regression were used to summarize and examine the prevalence estimates.

resultsTwenty-two studies with 22,803 acute undifferentiated febrile patients from 10 countries in Africa were included. The meta-analysis findings revealed a pooled prevalence of malaria and dengue coinfection of 4.2%, with Central Africa having the highest rate (4.7%), followed by East Africa (2.7%) and West Africa (1.6%). Continent-wide, Plasmodium falciparum and acute dengue virus coinfection prevalence increased significantly from 0.9% during 2008-2013 to 3.8% during 2014-2017 and to 5.5% during 2018-2021 (p = 0.0414).

conclusionThere was a high and increasing prevalence of malaria and acute dengue virus coinfection in Africa. Healthcare workers should bear in mind the possibility of dengue infection as a differential diagnosis for acute febrile illness, as well as the possibility of coexisting malaria and dengue in endemic areas. In addition, high-quality multicentre studies are required to verify the above conclusions. Protocol registration number: CRD42022311301.

Indexed as

CoinfectionDengueDengue VirusMalariaAfricaCross-Sectional StudiesFeverHumansPrevalenceCoinfectionDengue feverDengue virusMalariaMeta-analysisMeta-regressionPlasmodium falciparumPrevalence

Identifiers

PMID37803381
PMCPMC10557169

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.