Evidence map›Paper›PMID 37803193›Full record

ArticleInternal and emergency medicine2023

Unfolding dermatologic spectrum of Behçet's disease in Italy: real-life data from the International AIDA Network Behçet's disease Registry.

Martina D'Onghia, Elisa Cinotti, Alessandra Cartocci, Antonio Vitale, Valeria Caggiano, Linda Tognetti, Francesca La Marca, Jurgen Sota, Stefano Gentileschi, Giovanni Rubegni and 44 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal and emergency medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

54 authors at 20 institutions in 2 countries.

Martina D'Onghia *Unit of Dermatology, Department of Medical, Surgical and Neurological Science, University of Siena, Siena, Italy.
Elisa Cinotti *Unit of Dermatology, Department of Medical, Surgical and Neurological Science, University of Siena, Siena, Italy.
Alessandra CartocciUnit of Dermatology, Department of Medical, Surgical and Neurological Science, University of Siena, Siena, Italy.
Antonio VitaleDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Valeria CaggianoDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Linda TognettiUnit of Dermatology, Department of Medical, Surgical and Neurological Science, University of Siena, Siena, Italy.
Francesca La MarcaUnit of Dermatology, Department of Medical, Surgical and Neurological Science, University of Siena, Siena, Italy.
Jurgen SotaDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Stefano GentileschiDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Giovanni RubegniDepartment of Ophthalmology, University of Catania, 9298, Catania, Italy.
Giuseppe LopalcoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy.
Silvana GuerrieroDepartment of Ophthalmology and Otolaryngology, University of Bari, Bari, Italy.
Marcello GovoniRheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, Italy.
Sara MontiRheumatology Department, IRCCS Policlinico S. Matteo Fondazione, University of Pavia, Pavia, Italy.
Piero RuscittiRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Fabrizio AngeliRheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Francesco CarubbiDepartment of Life, Health & Environmental Sciences and Internal Medicine and Nephrology Unit, Department of Medicine, University of L'Aquila and ASL Avezzano-Sulmona-L'Aquila, San Salvatore Hospital, L'Aquila, Italy.
Roberto GiacomelliClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Francesco CicciaDepartment of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy.
Matteo PigaRheumatology Unit, Department of Medical Sciences, University and AOU of Cagliari, Cagliari, Italy.
Giacomo EmmiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Stefania CostiUnit of Pediatric Rheumatology, ASST Gaetano Pini-CTO, Milan, Italy.
Gian Domenico SebastianiU.O.C. Reumatologia, Ospedale San Camillo-Forlanini, Rome, Italy.
Florenzo IannoneDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy.
Veronica SpedicatoDepartment of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, Italy.
Giovanni AlessioDepartment of Ophthalmology and Otolaryngology, University of Bari, Bari, Italy.
Francesca RuffilliRheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, Italy.
Alessandra MilanesiRheumatology Department, IRCCS Policlinico S. Matteo Fondazione, University of Pavia, Pavia, Italy.
Martina GentileRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Francesca CrisafulliRheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Alessia AlunnoDepartment of Life, Health & Environmental Sciences and Internal Medicine and Nephrology Unit, Department of Medicine, University of L'Aquila and ASL Avezzano-Sulmona-L'Aquila, San Salvatore Hospital, L'Aquila, Italy.
Luca NavariniClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Campus Bio-Medico, Via Álvaro del Portillo 200, 00128, Rome, Italy.
Daniela IaconoDepartment of Precision Medicine, Università Degli Studi Della Campania Luigi Vanvitelli, Naples, Italy.
Alberto CauliRheumatology Unit, Department of Medical Sciences, University and AOU of Cagliari, Cagliari, Italy.
Francesca RicciPediatric Clinic, University of Brescia and Spedali Civili Di Brescia, Brescia, Italy.
Carla GaggianoDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Maria TarsiaAzienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center] Siena, Siena, Italy.
Elena BartoloniRheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy.
Giovanni ContiPediatric Nephrology and Rheumatology Unit, AOU Policlinic G Martino, Messina, Italy.
Ombretta ViapianaRheumatology Unit, University of Verona, Policlinico G. B. Rossi, Verona, Italy.
Francesca Li GobbiRheumatology Unit, San Giovanni di Dio Hospital, Florence, Italy.
Amato de PaulisDepartment of Translational Medical Sciences, Section of Clinical Immunology, University of Naples Federico II, Naples, Italy.
Paola ParronchiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Emanuela Del GiudiceDepartment of Maternal Infantile and Urological Sciences, Polo Pontino, Sapienza University of Rome, Rome, Italy.
Patrizia BaroneDepartment of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Alma Nunzia OlivieriDepartment of Woman, Child and of General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Emanuele BizziMedicina Interna, Ospedale Fatebenefratelli, Milan, Italy.
Maria Cristina MaggioUniversity Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE) "G. D'Alessandro", University of Palermo, Palermo, Italy.
Alberto BalistreriBioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Bruno FredianiDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy.
Gian Marco TosiOphthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Claudia FabianiOphthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Pietro RubegniUnit of Dermatology, Department of Medical, Surgical and Neurological Science, University of Siena, Siena, Italy.
Luca CantariniDepartment of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, University of Siena, Siena, Italy. cantariniluca@hotmail.com.ORCID http://orcid.org/0000-0002-7352-1275
University of Siena · ITUniversity of Bari Aldo Moro · ITUniversity of L'Aquila · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversità Campus Bio-Medico · ITUniversity of Brescia · ITUniversity of Cagliari · ITUniversity of Catania · ITUniversity of Ferrara · ITUniversity of Pavia · ITAzienda Ospedaliera Fatebenefratelli e Oftalmico · ITAzienda Ospedaliera Universitaria Policlinico "G. Martino" · ITAzienda Ospedaliera Universitaria Senese · ITAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITIstituto Ortopedico Gaetano Pini · ITMonash Medical Centre · AUNuovo Ospedale San Giovanni di Dio · ITOspedale generale di zona San Camillo Treviso · ITSapienza University of Rome · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Behçet's disease (BD) is a heterogeneous multifactorial autoinflammatory disease characterized by a plethora of clinical manifestations. Cutaneous lesions are considered hallmarks of the disease. However, their evolution over time and a thorough description are scarcely reported in non-endemic regions. The aim of this study was to detail BD skin manifestations and their evolution over time in Italy, as well as the dermatological prognostic impact of specific cutaneous features in long-standing disease. Data were collected in a double fashion, both retrospectively and prospectively, from the AutoInflammatory Disease Alliance (AIDA) international registry dedicated to BD, between January 2022 and December 2022. A total of 458 Italian patients were included. When assessing skin manifestations course, the constant or sporadic presence or absence of cutaneous involvement between onset and follow-up was considered. Oral ulcers (OU) (88.4%) and genital ulcers (GU) (52.6%), followed by skin involvement (53.7%) represented the most common presenting mucocutaneous manifestations at disease onset. Up to the time of enrolment into the AIDA registry, 411 (93.8%) patients had suffered from OU and 252 (57.9%) from GU; pseudofolliculitis (PF) accounted for the most common skin manifestation (170 patients, 37.1%), followed by erythema nodosum (EN) (102 patients, 22.3%), skin ulcers (9 patients, 2%) and pyoderma gangrenosum (4 patients, 0.9%). A prospective follow-up visit was reported in 261/458 patients; 24/148 (16.2%) subjects with skin involvement as early as BD onset maintained cutaneous lesions for the entire period of observation, while 120 (44.1%) patients suffered from sporadic skin involvement. Conversely, 94/113 (83.2%) with no skin involvement at disease onset did not develop skin lesions thereafter. At follow-up visits, cutaneous involvement was observed in 52 (20%) patients, with a statistically significant association between PF and constant skin involvement (p = 0.031). BD in Italy is characterized by a wide spectrum of clinical presentations and skin manifestations in line with what is described in endemic countries. Patients with skin disease at the onset are likely to present persistent cutaneous involvement thereafter; mucocutaneous lesions observed at the onset, especially PF, could represent a warning sign for future persistent skin involvement requiring closer dermatological care.

Indexed as

Behcet SyndromeOral UlcerHumansItalyProspective StudiesRegistriesRetrospective StudiesAphthosisAutoinflammatory diseasesDiagnosisErythema nodosumPseudofolliculitis

Identifiers

PMID37803193
PMCPMC10635974
OpenAlexW4387398183

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