Evidence map›Paper›PMID 37803072›Full record

ArticleScientific reports2023

The effect of circulating iron on barrier integrity of primary human endothelial cells.

M C Madsen, F Podieh, M C Overboom, A Thijs, M den Heijer, P L Hordijk

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Iron and the lung: emerging roles of iron metabolism in pulmonary disease pathogenesis and therapy.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Iron Metabolism in Cardiovascular Disease.Advances in experimental medicine and biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

M C MadsenDepartment of Physiology, Amsterdam UMC, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands. m.madsen@amsterdamumc.nl.
F PodiehDepartment of Physiology, Amsterdam UMC, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands.
M C OverboomDepartment of Physiology, Amsterdam UMC, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands.
A ThijsDepartment of Internal Medicine, Amsterdam UMC, Amsterdam, Netherlands.
M den HeijerDepartment of Internal Medicine, Amsterdam UMC, Amsterdam, Netherlands.
P L HordijkDepartment of Physiology, Amsterdam UMC, De Boelelaan 1118, Amsterdam, 1081 HV, Netherlands.
Amsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron is hypothesized to be one of the contributors to cardiovascular disease and its levels in the circulation may correlate with cardiovascular risk. The aim of this study is to investigate the mechanisms that underlie the effects of iron on the barrier function of primary human endothelium. We used Human Umbilical Vein Endothelial Cells (HUVEC) to investigate the effects of Fe

Indexed as

Endothelium, VascularCells, CulturedHumansHuman Umbilical Vein Endothelial CellsReactive Oxygen SpeciesTranscriptional ActivationUp-RegulationReactive Oxygen Species

Identifiers

PMID37803072
PMCPMC10558552
OpenAlexW4387407655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.