Evidence map›Paper›PMID 37803007›Full record

ArticleNature communications2023

Phylogenomics reveals the history of host use in mosquitoes.

John Soghigian, Charles Sither, Silvia Andrade Justi, Gen Morinaga, Brian K Cassel, Christopher J Vitek, Todd Livdahl, Siyang Xia, Andrea Gloria-Soria, Jeffrey R Powell and 13 more

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  14. Article
  15. Pathogens spread by high-flying wind-borne mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Phylogenomics redefines the evolutionary history of mosquitoes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Review
  20. A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

John SoghigianDepartment of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC, USA.ORCID 0000-0003-4469-2072
Charles SitherDepartment of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC, USA.
Silvia Andrade JustiWalter Reed Biosystematics Unit, Smithsonian Institution Museum Support Center, Suitland, MD, USA.
Gen MorinagaFaculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Brian K CasselDepartment of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC, USA.
Christopher J VitekCenter for Vector-Borne Diseases, University of Texas Rio Grande Valley, Edinburg, TX, USA.
Todd LivdahlDepartment of Biology, Clark University, Worcester, MA, USA.ORCID 0000-0003-2387-8214
Siyang XiaDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
Andrea Gloria-SoriaDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
Jeffrey R PowellDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.
Thomas ZavortinkBohart Museum of Entomology, University of California, Davis, CA, USA.
Christopher M HardyCSIRO Land and Water, Canberra, ACT, Australia.
Nathan D Burkett-CadenaFlorida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA.ORCID 0000-0001-6168-1637
Lawrence E ReevesFlorida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach, FL, USA.ORCID 0000-0003-3968-8124
Richard C WilkersonWalter Reed Biosystematics Unit, Smithsonian Institution Museum Support Center, Suitland, MD, USA.ORCID 0000-0001-6366-1357
Robert R DunnDepartment of Applied Ecology, North Carolina State University, Raleigh, NC, USA.
David K YeatesAustralian National Insect Collection, CSIRO National Collections and Marine Infrastructure, Canberra, ACT, Australia.ORCID 0000-0001-7729-6143
Maria Anice SallumDepartamento de Epidemiologia, Faculdade de Saude Publica, Universidade de Sao Paulo, Sao Paulo, Brazil.ORCID 0000-0002-7051-2891
Brian D ByrdCollege of Health and Human Sciences, School of Health Sciences, Western Carolina University, Cullowhee, NC, USA.
Michelle D TrautweinEntomology Department, Institute for Biodiversity Science and Sustainability, California Academy of Sciences, San Francisco, CA, USA.
Yvonne-Marie LintonWalter Reed Biosystematics Unit, Smithsonian Institution Museum Support Center, Suitland, MD, USA.
Michael H ReiskindDepartment of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC, USA.
Brian M WiegmannDepartment of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC, USA. bwiegman@ncsu.edu.ORCID 0000-0002-1869-9759

Funding

Comprehensive characterization of ancestral populations of the vector Aedes aegypti on Indian Ocean islandsR01AI155562 · NIAID · YALE UNIVERSITY · PI POWELL, JEFFREY R · 2021 to 2025
$2.9M
NIAID NIH HHS R01 AI155562
6 · The paper itself

Abstract

Mosquitoes have profoundly affected human history and continue to threaten human health through the transmission of a diverse array of pathogens. The phylogeny of mosquitoes has remained poorly characterized due to difficulty in taxonomic sampling and limited availability of genomic data beyond the most important vector species. Here, we used phylogenomic analysis of 709 single copy ortholog groups from 256 mosquito species to produce a strongly supported phylogeny that resolves the position of the major disease vector species and the major mosquito lineages. Our analyses support an origin of mosquitoes in the early Triassic (217 MYA [highest posterior density region: 188-250 MYA]), considerably older than previous estimates. Moreover, we utilize an extensive database of host associations for mosquitoes to show that mosquitoes have shifted to feeding upon the blood of mammals numerous times, and that mosquito diversification and host-use patterns within major lineages appear to coincide in earth history both with major continental drift events and with the diversification of vertebrate classes.

Indexed as

CulicidaeAnimalsFeeding BehaviorHumansMammalsMosquito VectorsPhylogenyVertebrates

Identifiers

PMID37803007
PMCPMC10558525

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.