Evidence map›Paper›PMID 37802985›Full record

ArticleNature communications2023

Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment.

Tra Vinikoor, Godwin K Dzidotor, Thinh T Le, Yang Liu, Ho-Man Kan, Srimanta Barui, Meysam T Chorsi, Eli J Curry, Emily Reinhardt, Hanzhang Wang and 17 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed
26.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 275 citations in OpenAlex.

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  13. Topologically Structured PLLA Fibers With Stress Concentration Effects for Health Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 2 institutions in 1 country.

Tra VinikoorDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.ORCID http://orcid.org/0000-0002-7637-6296
Godwin K DzidotorThe Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, 06030, USA.
Thinh T LeDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Yang LiuCenter of Digital Dentistry/Department of Prosthodontics/Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & NMPA Key Laboratory for Dental Materials, Beijing, 100081, PR China.ORCID http://orcid.org/0000-0003-1655-828X
Ho-Man KanThe Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, 06030, USA.
Srimanta BaruiThe Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, 06030, USA.
Meysam T ChorsiDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT, 06269, USA.ORCID http://orcid.org/0000-0002-2633-9200
Eli J CurryEli Lilly and Company, 450 Kendall Street, Cambridge, MA, 02142, USA.ORCID http://orcid.org/0000-0001-8396-3037
Emily ReinhardtDepartment of Pathobiology and Veterinary Science, University of Connecticut, 61 North Eagleville Road, Unit 3089, Storrs, CT, 06269, USA.
Hanzhang WangPathology and Laboratory Medicine, University of Connecticut Health Center, 63 Farmington Avenue, Farmington, CT, 06030, USA.
Parbeen SinghDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Marc A MerrimanThe Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, 06030, USA.ORCID http://orcid.org/0000-0003-2577-3045
Ethan D'OrioDepartment of Advanced Manufacturing for Energy Systems Engineering, University of Connecticut, Storrs, CT, 06269, USA.ORCID http://orcid.org/0009-0004-5208-5357
Jinyoung ParkDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.ORCID http://orcid.org/0000-0003-0943-3649
Shuyang XiaoDepartment of Materials Science and Engineering & Institute of Materials Science, University of Connecticut, 25 King Hill Road, Unit 3136, Storrs, CT, 06269-3136, USA.
James H ChapmanThe Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, 06030, USA.ORCID http://orcid.org/0000-0002-4750-9926
Feng LinDepartment of Mechanical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Cao-Sang TruongDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Somasundaram PrasadhCenter for Clean Energy Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Lisa ChubaCenter for Comparative Medicine, University of Connecticut Health Center, Farmington, CT, USA.
Shaelyn KillohCenter for Comparative Medicine, University of Connecticut Health Center, Farmington, CT, USA.
Seok-Woo LeeDepartment of Materials Science and Engineering & Institute of Materials Science, University of Connecticut, 25 King Hill Road, Unit 3136, Storrs, CT, 06269-3136, USA.ORCID http://orcid.org/0000-0001-6752-5694
Qian WuPathology and Laboratory Medicine, University of Connecticut Health Center, 63 Farmington Avenue, Farmington, CT, 06030, USA.
Ramaswamy M ChidambaramCenter for Comparative Medicine, University of Connecticut Health Center, Farmington, CT, USA.
Kevin W H LoThe Cato T. Laurencin Institute for Regenerative Engineering, University of Connecticut Health, Farmington, CT, 06030, USA.
Cato T LaurencinDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA.ORCID http://orcid.org/0000-0001-6765-3047
Thanh D NguyenDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, 06269, USA. nguyentd@uconn.edu.ORCID http://orcid.org/0000-0003-0813-4807
University of Connecticut · USUConn Health · US

Funding

Biodegradable Piezoelectric Nanocomposite Scaffold with Physical Exercise to Heal Major Cartilage Defects in Large AnimalsR01AR080102 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI Thanh Nguyen · 2022 to 2026
$1.9M
Real-time Measurement of Joint-loading for Osteoarthritis Study and Treatment R21AR078744R21AR078744 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2021 to 2022
$498k
Single-administration microneedles with controlled sustained release of non-opioid analgesics to treat osteoarthritis painR21AR080919 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2022 to 2023
$474k
A novel injectable piezoelectric hydrogel for osteoarthritis treatmentR21AR074645 · NIAMS · UNIVERSITY OF CONNECTICUT STORRS · PI NGUYEN, THANH · 2019 to 2020
$389k
NIAMS NIH HHS R01 AR080102NIAMS NIH HHS R21 AR074645NIAMS NIH HHS R21 AR078744NIAMS NIH HHS R21 AR080919
6 · The paper itself

Abstract

Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering.

Indexed as

Cartilage, ArticularHydrogelsAnimalsCartilageCells, CulturedChondrogenesisCollagenHumansRabbitsTissue EngineeringTissue ScaffoldsWound HealingCollagenHydrogels

Identifiers

PMID37802985
PMCPMC10558537
OpenAlexW4387396939

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.