Evidence map›Paper›PMID 37802982›Full record

ArticleNature communications2023

Distinct and targetable role of calcium-sensing receptor in leukaemia.

Raquel S Pereira, Rahul Kumar, Alessia Cais, Lara Paulini, Alisa Kahler, Jimena Bravo, Valentina R Minciacchi, Theresa Krack, Eric Kowarz, Costanza Zanetti and 12 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 2 countries.

Raquel S PereiraGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.ORCID 0000-0002-9863-6538
Rahul KumarGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Alessia CaisPediatric Neurooncology, Hopp Children's Cancer Center Heidelberg (KiTZ) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lara PauliniGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Alisa KahlerGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Jimena BravoGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Valentina R MinciacchiGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.ORCID 0000-0002-9296-9403
Theresa KrackGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Eric KowarzInstitute of Pharmaceutical Biology, Goethe University, Frankfurt am Main, Germany.
Costanza ZanettiUniversity Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.ORCID 0000-0001-9384-1543
Parimala Sonika GodavarthyGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Fabian HoellerGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany.
Pablo LlavonaInstitute of Molecular Biology gGmbH (IMB), Mainz, Germany.
Tabea StarkInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0002-5105-7002
Georg TascherInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0002-5907-3947
Daniel NowakDepartment of Hematology and Oncology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID 0000-0001-7130-7921
Eshwar MeduriDepartment of Haematology, University of Cambridge, Cambridge, United Kingdom.
Brian J P HuntlyDepartment of Haematology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0003-0312-161X
Christian MünchInstitute of Biochemistry II, Faculty of Medicine, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0003-3832-090X
Francesco PampaloniBuchmann Institute for Molecular Life Sciences (BMLS, CEF-MC), Goethe University, Frankfurt am Main, Germany.ORCID 0000-0003-4357-7320
Rolf MarschalekInstitute of Pharmaceutical Biology, Goethe University, Frankfurt am Main, Germany.ORCID 0000-0003-4870-3445
Daniela S KrauseGeorg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany. Krause@gsh.uni-frankfurt.de.ORCID 0000-0003-3603-1119
Georg Speyer Haus · DEGoethe University Frankfurt · DEUniversity of Cambridge · GBGerman Cancer Research Center · DEHeidelberg University · DEInstitute of Molecular Biology · DEJohannes Gutenberg University Mainz · DE

Funding

Cancer Research UK DRCRPG-NOV22/100014
6 · The paper itself

Abstract

Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they respond to extracellular calcium [eCa

Indexed as

Leukemia, Myeloid, AcuteReceptors, Calcium-SensingCalciumCytarabineHumansOncogene Proteins, FusionProto-Oncogene Proteins c-mycSignal TransductionTumor MicroenvironmentCalciumCytarabineOncogene Proteins, FusionProto-Oncogene Proteins c-mycReceptors, Calcium-Sensing

Identifiers

PMID37802982
PMCPMC10558580
OpenAlexW4387399259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.