Evidence map›Paper›PMID 37802573›Full record

ArticleMethods in enzymology2023

Bacterial expression, purification, and reconstitution of human steroid 5α-reductases in phospholipid liposomes and nanodiscs.

Sang-Choul Im, Juan Valentín-Goyco, Hwei-Ming Peng, Richard J Auchus

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in enzymology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sang-Choul ImDivision of Metabolism, Endocrinology, Diabetes, Department of Internal Medicine, and University of Michigan, Ann Arbor, MI, United States; Department of Pharmacology, University of Michigan, Ann Arbor, MI, United States; Veterans Affairs Medical Center, Fuller Road, Ann Arbor, MI, United States.
Juan Valentín-GoycoDivision of Metabolism, Endocrinology, Diabetes, Department of Internal Medicine, and University of Michigan, Ann Arbor, MI, United States; Department of Pharmacology, University of Michigan, Ann Arbor, MI, United States.
Hwei-Ming PengDivision of Metabolism, Endocrinology, Diabetes, Department of Internal Medicine, and University of Michigan, Ann Arbor, MI, United States.
Richard J AuchusDivision of Metabolism, Endocrinology, Diabetes, Department of Internal Medicine, and University of Michigan, Ann Arbor, MI, United States; Department of Pharmacology, University of Michigan, Ann Arbor, MI, United States; Veterans Affairs Medical Center, Fuller Road, Ann Arbor, MI, United States. Electronic address: rauchus@med.umich.edu.
University of Michigan–Ann Arbor · USVeterans Health Administration · US

Funding

Activation of androgen biosynthesis and drug metabolism by cytochrome b5R01GM086596 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI RICHARD J. AUCHUS · 2009 to 2026
$4.8M
NIGMS NIH HHS R01 GM086596
6 · The paper itself

Abstract

The two human steroid 5α-reductase (5αR) enzymes catalyze the conversion 3-keto-Δ

Indexed as

3-Oxo-5-alpha-Steroid 4-DehydrogenaseLiposomesDihydrotestosteroneHumansMalePhospholipidsTestosterone3-Oxo-5-alpha-Steroid 4-DehydrogenaseDihydrotestosteroneLiposomesPhospholipidsTestosterone5α-reductaseAndrogenDihydrotestosteroneProstateSteroidogenesis

Identifiers

PMID37802573
PMCPMC11239128
OpenAlexW4381303877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.