Evidence map›Paper›PMID 37802546›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2023

Presence of a remote fear memory engram in the central amygdala.

Robert J Hammack, Victoria E Fischer, Mary Ann Andrade, Glenn M Toney

Open access · greenAbstract read
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Fear of Predators Suppresses Neurogenesis in the Brains of Wild Songbirds.Integrative organismal biology (Oxford, England) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Robert J HammackDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.ORCID 0000-0002-5206-6947
Victoria E FischerDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.ORCID 0000-0002-0882-9783
Mary Ann AndradeDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.ORCID 0000-0002-7031-6866
Glenn M ToneyDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA toney@uthscsa.edu.ORCID 0000-0003-3100-746X
The University of Texas Health Science Center at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
Role of the serotonin transporter and organic cation transporter 3 in serotonergic modulation of emotion-regulating circuitryR01MH093320 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DAWS, LYNETTE C, TONEY, GLENN M · 2012 to 2023
$6.3M
Mechanisms of Synaptic Homeostasis Governing Pre-Sympathetic Neurons in the Hypothalamic Paraventricular NucleusR01NS115072 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI TONEY, GLENN M · 2020 to 2024
$2.4M
NCI NIH HHS P30 CA054174NIMH NIH HHS R01 MH093320NINDS NIH HHS R01 NS115072
6 · The paper itself

Abstract

Fear memory formation and recall are highly regulated processes, with the central amygdala (CeA) contributing to fear memory-related behaviors. We recently reported that a remote fear memory engram is resident in the anterior basolateral amygdala (aBLA). However, the extent to which downstream neurons in the CeA participate in this engram is unknown. We tested the hypothesis that CeA neurons activated during fear memory formation are reactivated during remote memory retrieval such that a CeA engram participates in remote fear memory recall and its associated behavior. Using contextual fear conditioning in TRAP2;Ai14 mice, we identified, by persistent Cre-dependent tdTomato expression (i.e., "TRAPing"), CeA neurons that were

Indexed as

Central Amygdaloid NucleusAnimalsFearMemoryMemory, Long-TermMental RecallMice

Identifiers

PMID37802546
PMCPMC10561632
OpenAlexW4387439979

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.