Evidence map›Paper›PMID 37802154›Full record

ArticleNeurobiology of disease2023

Altered calcium signaling in Bergmann glia contributes to spinocerebellar ataxia type-1 in a mouse model of SCA1.

Carmen Nanclares, Jose Antonio Noriega-Prieto, Francisco E Labrada-Moncada, Marija Cvetanovic, Alfonso Araque, Paulo Kofuji

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Carmen NanclaresDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Jose Antonio Noriega-PrietoDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Francisco E Labrada-MoncadaDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Marija CvetanovicDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Alfonso AraqueDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: araque@umn.edu.
Paulo KofujiDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: kofuj001@umn.edu.
University of Minnesota · US

Funding

Etiology of cognitive decline in Spinocerebellar ataxia type 1R01NS109077 · NINDS · UNIVERSITY OF MINNESOTA · PI Marija Cvetanovic, TIMOTHY J EBNER · 2020 to 2026
$2.4M
Astrocyte activity in amygdala-related fear conditioned behaviorsR01MH119355 · NIMH · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, KOFUJI, PAULO · 2020 to 2024
$2.3M
Role of astrocytes in dopamine signaling and psychostimulant effectsR01DA048822 · NIDA · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO · 2019 to 2023
$1.8M
NIDA NIH HHS R01 DA048822NIMH NIH HHS R01 MH119355NINDS NIH HHS R01 NS109077
6 · The paper itself

Abstract

Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by an abnormal expansion of glutamine (Q) encoding CAG repeats in the ATAXIN1 (ATXN1) gene and characterized by progressive cerebellar ataxia, dysarthria, and eventual deterioration of bulbar functions. SCA1 shows severe degeneration of cerebellar Purkinje cells (PCs) and activation of Bergmann glia (BG), a type of cerebellar astroglia closely associated with PCs. Combining electrophysiological recordings, calcium imaging techniques, and chemogenetic approaches, we have investigated the electrical intrinsic and synaptic properties of PCs and the physiological properties of BG in SCA1 mouse model expressing mutant ATXN1 only in PCs. PCs of SCA1 mice displayed lower spontaneous firing rate and larger slow afterhyperpolarization currents (sI

Indexed as

CalciumSpinocerebellar AtaxiasAnimalsAtaxin-1Calcium SignalingCerebellumMiceMice, TransgenicNeurogliaPurkinje CellsAtaxin-1CalciumAtaxiaBergmann gliaCalciumGliotransmissionPurkinje cell

Identifiers

PMID37802154
PMCPMC10624966
OpenAlexW4387327954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.