Evidence map›Paper›PMID 37802034›Full record

ArticleCell stem cell2023

Human embryo models made from pluripotent stem cells are not synthetic; they aren't embryos, either.

Hannah L Landecker, Amander T Clark

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Human Stem Cell-Based Embryo Model Research: Ethics and Regulations.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  3. The Use of Stem Cells in Assisted Reproduction.Journal of clinical medicine · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hannah L LandeckerDepartment of Sociology, University of California, Los Angeles, Los Angeles, CA 90095, USA; The Institute for Society and Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Center for Reproductive Science, Health and Education, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: landecker@soc.ucla.edu.
Amander T ClarkCenter for Reproductive Science, Health and Education, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: clarka@ucla.edu.

Funding

Differentiating embryonic stem cells into developing germ lineR01HD079546 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, AMANDER · 2015 to 2024
$3.7M
Ethical and Social Implications of In Vitro GametogenesisR21HG012248 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LANDECKER, HANNAH LOUISE · 2021 to 2022
$429k
NHGRI NIH HHS R21 HG012248NICHD NIH HHS R01 HD079546
6 · The paper itself

Abstract

Embryo models are potentially highly impactful for human health research because their development recapitulates otherwise inaccessible events in a poorly understood area of biology, the first few weeks of human life. Casual reference to these models as "synthetic embryos" is misleading and should be approached with care and deliberation.

Indexed as

Pluripotent Stem CellsEmbryo, MammalianHumans

Identifiers

PMID37802034
PMCPMC10927377

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.