Evidence map›Paper›PMID 37801498›Full record

ArticleScience advances2023

The maternal microbiome promotes placental development in mice.

Geoffrey N Pronovost, Kristie B Yu, Elena J L Coley-O'Rourke, Sahil S Telang, Angela S Chen, Helen E Vuong, Drake W Williams, Anisha Chandra, Tomiko K Rendon, Jorge Paramo and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
12.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 78 citations in OpenAlex.

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  11. The Microbiota Shapes Central Nervous System Myelination in Early Life.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Geoffrey N PronovostDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6421-9739
Kristie B YuDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6735-3968
Elena J L Coley-O'RourkeDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Sahil S TelangDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Angela S ChenDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-1471-1693
Helen E VuongDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-7837-8239
Drake W WilliamsThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-7718-2098
Anisha ChandraDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Tomiko K RendonDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Jorge ParamoDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.
Reuben H KimThe Shapiro Family Laboratory of Viral Oncology and Aging Research, University of California, Los Angeles, Los Angeles, CA, USA.
Elaine Y HsiaoDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-1633-588X
University of California, Los Angeles · US

Funding

Investigating role of maternal gut microbiome in microglia-neuron dynamics and development of somatosensory circuitsR00HD101680 · NICHD · UNIVERSITY OF MINNESOTA · PI VUONG, HELEN · 2022 to 2024
$721k
Intersections between the maternal microbiome, placental immunity, vasculature and fetal growthF31HD101270 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PRONOVOST, GEOFFREY NATHAN · 2019 to 2021
$79k
NICHD NIH HHS F31 HD101270NICHD NIH HHS R00 HD101680
6 · The paper itself

Abstract

The maternal microbiome is an important regulator of gestational health, but how it affects the placenta as the interface between mother and fetus remains unexplored. Here, we show that the maternal gut microbiota supports placental development in mice. Depletion of the maternal gut microbiota restricts placental growth and impairs feto-placental vascularization. The maternal gut microbiota modulates metabolites in the maternal and fetal circulation. Short-chain fatty acids (SCFAs) stimulate cultured endothelial cell tube formation and prevent abnormalities in placental vascularization in microbiota-deficient mice. Furthermore, in a model of maternal malnutrition, gestational supplementation with SCFAs prevents placental growth restriction and vascular insufficiency. These findings highlight the importance of host-microbial symbioses during pregnancy and reveal that the maternal gut microbiome promotes placental growth and vascularization in mice.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsFemaleFetusMicePlacentaPlacentationPregnancy

Identifiers

PMID37801498
PMCPMC10558122
OpenAlexW4387397352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.