Evidence map›Paper›PMID 37801196›Full record

ArticleMolecular imaging and biology2023

Parametric Imaging of P-Glycoprotein Function at the Blood-Brain Barrier Using k

Louise Breuil, Myriam El Biali, Dominique Vodovar, Solène Marie, Sylvain Auvity, Martin Bauer, Sébastien Goutal, Sebastian Rodrigo, Oliver Langer, Nicolas Tournier

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Designing a Small Molecule for PET Radiotracing: [Molecules (Basel, Switzerland) · 2025
    Review
  2. Imaging the Activity of Efflux Transporters at the Blood-Brain Barrier in Neurologic Diseases: Radiotracer Selection Criteria.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  3. [Fluids and barriers of the CNS · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Louise BreuilInserm, CNRS, CEA, BioMaps, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, Université Paris-Saclay, CEA/SHFJ, 4 Place du Général Leclerc 91400, Orsay, France.
Myriam El BialiDepartment of Clinical Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Dominique VodovarInserm, CNRS, CEA, BioMaps, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, Université Paris-Saclay, CEA/SHFJ, 4 Place du Général Leclerc 91400, Orsay, France.
Solène MarieInserm, CNRS, CEA, BioMaps, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, Université Paris-Saclay, CEA/SHFJ, 4 Place du Général Leclerc 91400, Orsay, France.
Sylvain AuvityInserm, CNRS, CEA, BioMaps, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, Université Paris-Saclay, CEA/SHFJ, 4 Place du Général Leclerc 91400, Orsay, France.
Martin BauerDepartment of Clinical Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Sébastien GoutalInserm, CNRS, CEA, BioMaps, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, Université Paris-Saclay, CEA/SHFJ, 4 Place du Général Leclerc 91400, Orsay, France.
Sebastian RodrigoInserm, CNRS, CEA, BioMaps, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, Université Paris-Saclay, CEA/SHFJ, 4 Place du Général Leclerc 91400, Orsay, France.
Oliver LangerDepartment of Clinical Pharmacology, Medical University of Vienna, 1090, Vienna, Austria.
Nicolas TournierInserm, CNRS, CEA, BioMaps, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, Université Paris-Saclay, CEA/SHFJ, 4 Place du Général Leclerc 91400, Orsay, France. nicolas.tournier@cea.fr.ORCID 0000-0002-0755-2030
Centre National de la Recherche Scientifique · FRDélégation Paris 5 · FRMedical University of Vienna · AT

Funding

Agence Nationale de la Recherche ANR19-CE17-0027Austrian Science Fund FWF I 4470
6 · The paper itself

Abstract

purposePET imaging using [ PROCEDURES: k

resultsThe linear part of the log-transformed brain TACs occurred from 10 to 30 min after radiotracer injection in rats, from 15 to 60 min in baboons, and from 20 to 60 min in humans. P-gp inhibition significantly decreased k

conclusionsk

Indexed as

ATP Binding Cassette Transporter, Subfamily B, Member 1Blood-Brain BarrierAnimalsATP Binding Cassette Transporter, Subfamily BBrainHumansMetoclopramidePapioPositron-Emission TomographyRatsATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1MetoclopramideABCB1ABC transporterATP-binding cassetteMultidrug resistanceNeuroimagingPharmacokineticsPositron emission tomography

Identifiers

PMID37801196
OpenAlexW4387393229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.