SynthesisHernia : the journal of hernias and abdominal wall surgery2024
Botulinum toxin A in complex incisional hernia repair: a systematic review.
Synthesis in Hernia : the journal of hernias and abdominal wall surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preoperative botulinum toxin for complex abdominal wall reconstruction: a meta-analysis of propensity-score matched studies with trial sequential analysis.Hernia : the journal of hernias and abdominal wall surgery · 2025Pooled it
- Basal Tone, Muscle Memory and Denervation: Pathophysiological Foundations of Abdominal Wall Hernia Development and Recovery.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Electromyographic and tomographic muscle changes after botulinum toxin administration through either 3 or 8 injection points in patients with large midline ventral hernias: a superiority study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Preoperative Botulinum Toxin Type A Use in Giant Inguinal Hernia Repair: A Scoping Review.Medical sciences (Basel, Switzerland) · 2026Article
- A practical algorithm for the combined use of preoperative progressive pneumoperitoneum and botulinum toxin A in large incisional hernia repair: learnings after 15 years of experience.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Ultrasound-Guided Botulinum Toxin A as an Adjunct to Intraoperative Fascial Traction in Incisional Hernia Repair: Registry-Based Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Patient Experience and Surgical Outcomes of Botulinum Toxin A Treatment in Complex Abdominal Wall Hernias: A Retrospective Analysis.Journal of abdominal wall surgery : JAWS · 2026Article
- Long-Term Outcomes of Preoperative Botulinum Toxin Use in Abdominal Wall Reconstruction: A Propensity-Matched Analysis of More Than 5000 Patients Over 5 Years.Aesthetic surgery journal. Open forum · 2026Article
- Predicting fascial non-closure in ventral hernia repair with transversus abdominis release: risk factors, clinical outcomes, and implications for surgical planning.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Effectiveness of pre-operative chemical component separation with computed tomography-guided intramuscular injection of OnabotulinumtoxinA in outcomes of large complex incisional ventral abdominal hernia repair: a propensity score-weighted comparative analysis.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Complex Abdominal Wall Hernias: Structured Use of Adjuvant Therapies.Journal of abdominal wall surgery : JAWS · 2025Article
- Preoperative abdominal wall Botulinum A toxin in the outpatient pain clinic prior to complex abdominal wall repair: A letter to the editor.Interventional pain medicine · 2024Article
- Limitations of Transversus Abdominis Release (TAR)-Additional Bridging of the Posterior Layer And/Or Anterior Fascia Is the Preferred Solution in Our Clinical Routine If Primary Closure is Not Possible.Journal of abdominal wall surgery : JAWS · 2024Article
- Acute Parastomal Hernia Presentations: A 10-Year Review of Management and Outcomes.Journal of abdominal wall surgery : JAWS · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the safety, efficacy, and short and long-term postoperative results of using BTA.
methodsWe conducted a systematic review following the recommendations of the PRISMA method. We systematically reviewed the MEDLINE/PubMed and SCOPUS electronic databases for studies published between January 2010 and September 2021. This systematic review was registered in PROSPERO, with registration number CRD42021252445.
resultsAfter applying the selection criteria, 11 relevant articles were selected. The total sample size was 1058 patients. Most studies aimed to assess the rate of fascial closure, followed by the rate of recurrence and reporting of postoperative complications, as well as the need for the components separation technique (CST). None of the studies reported serious complications from using BTA. Regarding fascial closure, all articles had rates above 75%, except for one. Surgical site events ranged between 19% and 29.4%. No recurrence in the group that used BTA was recorded in five studies. The other articles reported recurrence rates ranging from 6.4 to 11.4% in the groups that received BTA. The studies had varying follow-up times ranging from 1 to 49 months, with a mean of 18.6 months (± 11.2).
conclusionThis review described most of the key points about the preoperative use of BTA in hernia repair. It can be concluded that the use of BTA is a safe and effective practice that promotes good short and long-term results. However, the limitations of the current literature prevent more accurate conclusions on the subject.
Indexed as
Identifiers
37801164What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.