Evidence map›Paper›PMID 37801139›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2024

Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-β deposition in Alzheimer's disease.

Miao Zhang, Xiao-Hang Qian, Jialin Hu, Yaoyu Zhang, Xiaozhu Lin, Wangxi Hai, Kuangyu Shi, Xufeng Jiang, Yao Li, Hui-Dong Tang and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 26 citations in OpenAlex.

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  10. Comparing and combining TSPO-PET tracers in tauopathies.European journal of nuclear medicine and molecular imaging · 2026
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  15. A scoping review on potential of novel developments in fever of unknown origin and inflammation of unknown origin: long-axial-field-of-view positron emission tomography/computed tomography and novel radiotracers.The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of... · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Miao ZhangDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiao-Hang QianDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jialin HuSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Yaoyu ZhangSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.
Xiaozhu LinDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wangxi HaiDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kuangyu ShiDepartment of Nuclear Medicine, Bern University Hospital, University of Bern, Bern, Switzerland.
Xufeng JiangDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. jxf10885@rjh.com.cn.
Yao LiSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China. yaoli@sjtu.edu.cn.
Hui-Dong TangDepartment of Geriatrics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. thd10495@rjh.com.cn.
Biao LiDepartment of Nuclear Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lb10363@rjh.com.cn.ORCID 0000-0002-0493-2062
Shanghai Jiao Tong University · CNUniversity of Bern · CH

Funding

Guangci Clinical Technology and Innovation Program(GCTIP) of Ruijin Hospital GCQH2023061National Natural Science Foundation of China 81971014National Natural Science Foundation of China 82372073Shanghai Municipal Health Commission 202240031Shanghai Municipal Health Commission shslczdzk03403
6 · The paper itself

Abstract

purposeDespite the revealed role of immunological dysfunctions in the development and progression of Alzheimer's disease (AD) through animal and postmortem investigations, direct evidence regarding the impact of genetic factors on microglia response and amyloid-β (Aβ) deposition in AD individuals is lacking. This study aims to elucidate this mechanism by integrating transcriptomics and TSPO, Aβ PET imaging in clinical AD cohort.

methodsWe analyzed 85 patients with PET/MR imaging for microglial activation (TSPO, [

resultsTSPO uptake increased significantly both in aMCI (P < 0.05) and AD participants (P < 0.01) and showed a positive correlation with Aβ deposition (r = 0.42, P < 0.001). Decreased expression of TGFBR3, FABP3, CXCR4 and CD200 was observed in AD group. CD200 expression was significantly negatively associated with TSPO PET uptake (r =-0.33, P = 0.013). Mediation analysis indicated that CD200 acted as a significant mediator between TSPO uptake and Aβ deposition (total effect B = 1.92, P = 0.004) and MMSE score (total effect B =-54.01, P = 0.003).

conclusionBy integrating transcriptomics and TSPO PET imaging in the same clinical AD cohort, this study revealed CD200 played an important role in regulating neuroinflammation, Aβ deposition and cognitive dysfunction.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAntigens, CDGene Expression ProfilingHumansNeuroinflammatory DiseasesPositron-Emission TomographyProspective StudiesReceptors, GABAAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAntigens, CDantigens, CD200APP protein, humanReceptors, GABATSPO protein, human[18F]DPA-714 PET/MRAlzheimer’s diseaseAmyloid-βCD200NeuroinflammationTSPO

Identifiers

PMID37801139
PMCPMC10774172
OpenAlexW4387392702

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.