Evidence map›Paper›PMID 37801135›Full record

ArticleJournal of cancer research and clinical oncology2023

Vessels encapsulating tumor clusters: a novel efficacy predictor of hepatic arterial infusion chemotherapy in unresectable hepatocellular carcinoma.

Wenping Lin, Lianghe Lu, Rongliang Zheng, Shasha Yuan, Shaohua Li, Yihong Ling, Wei Wei, Rongping Guo

Open access · greenAbstract read
In one paragraph

Article in Journal of cancer research and clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Wenping Lin *Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Lianghe Lu *Department of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Rongliang Zheng *State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
Shasha Yuan *Department of Pathology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Shaohua LiDepartment of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Yihong LingDepartment of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. lingyh@sysucc.org.cn.
Wei WeiDepartment of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. weiwei@sysucc.org.cn.
Rongping GuoDepartment of Hepatobiliary Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. guorp@sysucc.org.cn.ORCID http://orcid.org/0000-0003-2799-3463
Sun Yat-sen University · CN

Funding

China Postdoctoral Science Foundation 2023M734035Clinical Trials Project (5010 Project) of Sun Yat-sen University No. 5010-2017009Clinical Trials Project (5010 Project) of Sun Yat-sen University No. 5010-2023001National Natural Science Foundation of China No. 82172579National Natural Science Foundation of China No.82203111National Natural Science Foundation of China No.82303879Science and Technology Planning Project of Guangzhou No. 2023A04J1777Science and Technology Planning Project of Guangzhou No. 2023A04J1781
6 · The paper itself

Abstract

purposeVessels encapsulating tumor clusters (VETC) is a novel vascular pattern structurally and functionally distinct from microvascular invasion (MVI) in hepatocellular carcinoma (HCC). This study aims to explore the prognostic value of VETC in patients receiving hepatic arterial infusion chemotherapy (HAIC) for unresectable HCC.

methodsFrom January 2016 to December 2017, 145 patients receiving HAIC as the initial treatment for unresectable HCC were enrolled and stratified into two groups according to their VETC status. Overall survival (OS), progression-free survival (PFS), overall response rate (ORR), and disease control rate (DCR) were evaluated.

resultsThe patients were divided into two groups: VETC

conclusionVETC status correlates remarkably well with the tumor response and long-term survival in patients undergoing HAIC. It may be a promising efficacy predictor and help identify patients who will benefit from HAIC.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsHumansInfusions, Intra-ArterialPrognosisTreatment OutcomeHepatic arterial infusion chemotherapySurvivalTumor responseUnresectable hepatocellular carcinomaVessels encapsulating tumor clusters

Identifiers

PMID37801135
PMCPMC11798139
OpenAlexW4387393304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.