Evidence map›Paper›PMID 37801004›Full record

ArticleThe Journal of general virology2023

Human immunodeficiency virus 1 5'-leader mutations in plasma viruses before and after the development of reverse transcriptase inhibitor-resistance mutations.

Janin Nouhin, Philip Lei Tzou, Soo-Yon Rhee, Malaya K Sahoo, Benjamin A Pinsky, Miri Krupkin, Joseph D Puglisi, Elisabetta V Puglisi, Robert W Shafer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Janin NouhinDivision of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA, USA.
Philip Lei TzouDivision of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA, USA.
Soo-Yon RheeDivision of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA, USA.
Malaya K SahooDepartment of Pathology, Stanford University, Stanford, CA, USA.
Benjamin A PinskyDivision of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA, USA.
Miri KrupkinDepartment of Structural Biology, School of Medicine, Stanford University, Stanford, CA, USA.
Joseph D PuglisiDepartment of Structural Biology, School of Medicine, Stanford University, Stanford, CA, USA.
Elisabetta V PuglisiDepartment of Structural Biology, School of Medicine, Stanford University, Stanford, CA, USA.
Robert W ShaferDivision of Infectious Diseases, Department of Medicine, Stanford University, Stanford, CA, USA.

Funding

CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral DynamicsU54AI170856 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WALTHER H MOTHES · 2022 to 2026
$34.4M
Dynamics of TranslationR35GM145306 · NIGMS · STANFORD UNIVERSITY · PI JOSEPH D PUGLISI · 2022 to 2026
$3.8M
Delineating the mechanism and inhibitory capacity of CMV neutralizing antibodiesR21AI147632 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TORTORELLA, DOMENICO · 2020 to 2021
$465k
Synthetic Genomics Approach to Assemble Infectious Clones of KSHVR03AI146632 · NIAID · JOHNS HOPKINS UNIVERSITY · PI DESAI, PRASHANT J, VASHEE, SANJAY · 2019 to 2020
$195k
HIV-1 Leader Mutations During RT Inhibitor TherapyR03AI147682 · NIAID · STANFORD UNIVERSITY · PI SHAFER, ROBERT WILLIAM · 2019 to 2020
$157k
NIAID NIH HHS R03 AI146632NIAID NIH HHS R03 AI147682NIAID NIH HHS R21 AI147632NIAID NIH HHS U54 AI170856NIGMS NIH HHS R35 GM145306
6 · The paper itself

Abstract

Human immunodeficiency virus 1 (HIV-1) reverse transcriptase (RT) initiation depends on interaction between viral 5'-leader RNA, RT and host tRNA3

Indexed as

Anti-HIV AgentsHIV-1HIV InfectionsDrug Resistance, ViralHIV Reverse TranscriptaseHumansMutationNucleotidesReverse Transcriptase InhibitorsAnti-HIV AgentsHIV Reverse TranscriptaseNucleotidesReverse Transcriptase Inhibitors

Identifiers

PMID37801004
PMCPMC10721937

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.