ArticleJournal of virology2023
Antigenic mapping of the hemagglutinin of the H9 subtype influenza A viruses using sera from Japanese quail (
Silvia Carnaccini, C Joaquín Cáceres, L Claire Gay, Lucas M Ferreri, Eugene Skepner, David F Burke, Ian H Brown, Ginger Geiger, Adebimpe Obadan, Daniela S Rajao and 2 more
Open access · hybridAbstract read
In one paragraphArticle in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors at 5 institutions in 2 countries.
Silvia Carnaccini *Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.
C Joaquín Cáceres *Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.ORCID 0000-0001-8508-6592 L Claire GayDepartment of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.
Lucas M FerreriDepartment of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.
Eugene SkepnerCenter for Pathogen Evolution, University of Cambridge , Cambridge, United Kingdom.
David F BurkeEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus , Hinxton, United Kingdom.
Ian H BrownAnimal and Plant Health Agency (APHA) , Weybridge, United Kingdom.
Ginger GeigerDepartment of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.
Adebimpe ObadanDepartment of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.
Daniela S RajaoDepartment of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.ORCID 0000-0002-0772-0065 Nicola S LewisWorld Influenza Centre, The Francis Crick Institute , London, United Kingdom.
Daniel R Perez *Department of Population Health, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.ORCID 0000-0002-6569-5689 University of Georgia · USAnimal and Plant Health Agency · GBEuropean Bioinformatics Institute · GBThe Francis Crick Institute · GBUniversity of Cambridge · GB
Funding
NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6MNIAID NIH HHS 75N93021C00014NIAID NIH HHS HHSN272201400008C
6 · The paper itselfAbstract
importanceDetermining the relevant amino acids involved in antigenic drift on the surface protein hemagglutinin (HA) is critical to understand influenza virus evolution and efficient assessment of vaccine strains relative to current circulating strains. We used antigenic cartography to generate an antigenic map of the H9 hemagglutinin (HA) using sera produced in one of the most relevant minor poultry species, Japanese quail. Key antigenic positions were identified and tested to confirm their impact on the antigenic profile. This work provides a better understanding of the antigenic diversity of the H9 HA as it relates to reactivity to quail sera and will facilitate a rational approach for selecting more efficacious vaccines against poultry-origin H9 influenza viruses in minor poultry species.
Indexed as
Antigenic Drift and ShiftHemagglutinin Glycoproteins, Influenza VirusInfluenza A Virus, H9N2 SubtypeInfluenza in BirdsAnimalsCoturnixPoultryHemagglutinin Glycoproteins, Influenza Virusantigenic cartographyAsiaH9N2influenzaJapanese quailminor poultrypoultryreverse geneticsvaccine selectionzoonotic infections
Identifiers
PMID37800947
PMCPMC10617583
OpenAlexW4387392873
What OpenQuestion holds
Textmetadata
LicenceCC BY
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