ArticleAngewandte Chemie (International ed. in English)2023
Direct Assembly of Metal-Phenolic Network Nanoparticles for Biomedical Applications.
Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 118 citations in OpenAlex.
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- A Metal-Polyphenol Complex Eliminates Chondrocytic ROS to Ameliorate Osteoarthritis.Cartilage · 2026Article
- Stoichiometric Regulation of Gallic Acid-Copper Nanozymes for Optimized Coordination Structure, Peroxidase-Like Activity, and Antibacterial Performance.Journal of food science · 2026Article
- Fe-MOF@Quercetin complex with light-controlled redox modulation for tumor wound repair.Materials today. Bio · 2026Article
- An MRI-visible nanotheranostic establishes a self-amplifying pyroptosis-STING-IFN-β circuit for CD8Materials today. Bio · 2026Article
- Preparation of Multifunctional Hydrogel Loaded with Isochlorogenic Acid A/FeGels (Basel, Switzerland) · 2026Article
- Advanced metal-phenolic networks for tissue regeneration: opportunities and challenges.Journal of nanobiotechnology · 2026Review
- Dual-pathway induction of pyroptosisActa pharmaceutica Sinica. B · 2026Article
- Programmable next-generation supramolecular self-assembled materials as drug delivery systems.Bioactive materials · 2026Review
- Mitochondria-targeted nanozyme hydrogel remodels the microenvironment to enhance bone regeneration in diabetes-associated periodontitis.Journal of nanobiotechnology · 2026Article
- Magnesium-tannic acid nanomedicines reprogram pro-fibrotic macrophages for hepatic fibrosis treatment via restoring endoplasmic reticulum homeostasis.Journal of nanobiotechnology · 2026Article
- BSA-Coated Metal-Phenolic Complex Assembly of 8-Shogaol Nanoparticles: Characterization, Stability, and Slow-Release Properties.Foods (Basel, Switzerland) · 2026Article
- Ferritin-Doped Nanoparticles Triggered Tumor-Specific Darkening for Enhanced Photothermal Tumor Ablation and Immune Activation.Advanced healthcare materials · 2026Article
- One-step green assembly of natural polyphenol-based nobiletin nanoparticles for ulcerative colitis therapy.Materials today. Bio · 2026Article
- Article
- Ferroptosis-based nano-assembly enhanced breast cancer therapy by inhibiting intratumor bacteria.Acta pharmaceutica Sinica. B · 2026Article
- Rectal delivered nanocomposite suppository against radiation-induced proctitis.Journal of nanobiotechnology · 2026Article
- How the Variability of Iron-Polyphenolic Complexes Affects the Degradation of Iron-Gall Inks: A Multi-Analytical Study.ACS omega · 2026Article
- Inhibition of LONP1 in prostate cancer: bibliometrics-guided target screening and AI-driven antibody design.International journal of surgery (London, England) · 2026Article
- Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coordination assembly offers a versatile means to developing advanced materials for various applications. However, current strategies for assembling metal-organic networks into nanoparticles (NPs) often face challenges such as the use of toxic organic solvents, cytotoxicity because of synthetic organic ligands, and complex synthesis procedures. Herein, we directly assemble metal-organic networks into NPs using metal ions and polyphenols (i.e., metal-phenolic networks (MPNs)) in aqueous solutions without templating or seeding agents. We demonstrate the role of buffers (e.g., phosphate buffer) in governing NP formation and the engineering of the NP physicochemical properties (e.g., tunable sizes from 50 to 270 nm) by altering the assembly conditions. A library of MPN NPs is prepared using natural polyphenols and various metal ions. Diverse functional cargos, including anticancer drugs and proteins with different molecular weights and isoelectric points, are readily loaded within the NPs for various applications (e.g., biocatalysis, therapeutic delivery) by direct mixing, without surface modification, owing to the strong affinity of polyphenols to various guest molecules. This study provides insights into the assembly mechanism of metal-organic complexes into NPs and offers a simple strategy to engineer nanosized materials with desired properties for diverse biotechnological applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.