ArticleInternational journal of methods in psychiatric research2023
Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications.
Article in International journal of methods in psychiatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Frustrative non-reward: A cross-species probe to study brain mechanisms of irritability.Translational psychiatry · 2026Review
- SHAP-based explainable machine learning analysis of reward-related neural connectivity to predict preadolescent irritability.Neuroimage. Reports · 2026Article
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Family Accommodation of Pediatric Irritability: Development and Psychometric Properties of the Family Accommodation Scale for Irritability.Behavior therapy · 2026Article
- Deep learning identification of reward-related neural substrates of preadolescent irritability: A novel 3D CNN application for fMRI.Neuroimage. Reports · 2025Article
- Developmental shifts in irritable behaviors from preschool to school age: Longitudinal network analysis of heterotypic and homotypic continuity.International journal of behavioral development · 2025Article
- Modeling the normal:abnormal spectrum of early childhood internalizing behaviors: A clinical-developmental approach for the Multidimensional Assessment Profiles Internalizing Dimensions.International journal of methods in psychiatric research · 2023Article
- MAPping affective dimensions of behavior: Methodologic and pragmatic advancement of the Multidimensional Assessment Profiles scales.International journal of methods in psychiatric research · 2023Article
- Commentary on the special issue: Leveraging measurement to refine developmental perspectives on psychopathology.International journal of methods in psychiatric research · 2023Article
- A pragmatic, clinically optimized approach to characterizing adolescent irritability: Validation of parent- and adolescent reports on the Multidimensional Assessment Profile Scales-Temper Loss Scale.International journal of methods in psychiatric research · 2023Article
- Developmentally specified characterization of the irritability spectrum at early school age: Implications for pragmatic mental health screening.International journal of methods in psychiatric research · 2023Article
- Advancing earlier transdiagnostic identification of mental health risk: A pragmatic approach at the transition to toddlerhood.International journal of methods in psychiatric research · 2023Article
- Prevalence, stability, and predictive utility of the Multidimensional Assessment of Preschoolers Scales clinically optimized irritability score: Pragmatic early assessment of mental disorder risk.International journal of methods in psychiatric research · 2023Article
- Characterizing the spectrum of irritability in preadolescence: Dimensional and pragmatic applications.International journal of methods in psychiatric research · 2023Article
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7 authors at 4 institutions in 1 country.
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Abstract
objectivesCharacterize the dimensional spectrum of preadolescent (PA) irritability, a robust transdiagnostic vulnerability marker, using the youth version of the Multidimensional Assessment Profiles Temper Loss (MAPS-TL-Youth) scale including common and with developmentally specific items. Based on this, derive and validate a clinically optimized irritability screener to flag psychopathology risk in preadolescents.
methodsThe normal:abnormal irritability spectrum was modeled using MAPS-TL-Youth data from the Multidimensional Assessment of Preschoolers Study (MAPS) Study PA wave (n = 340) via item response theory. Both cross-cutting core items from the MAPS scales and developmentally specific items were used to generate this dimension. Stepwise logistic regression was then used to optimize MAPS-TL-Youth irritability items in relation to Kiddie Schedule of Affective Disorders and Schizophrenia impairment to generate a clinically optimized irritability screener. Receiver operator characteristic analysis identified the irritability threshold for the screener. For the first time, youth self-report of their own irritability on the MAPS-TL was also modeled via the MAPS-TL-Youth-Self-Report (MAPS-TL-Youth-SR).
resultsIrritability was unidimensional and ranged from mild and common to severe and rare behaviors. Developmentally specific items allowed detection of more severe irritability. Items for the screener were identified in relation to concurrent impairment. These included low frustration tolerance and pathognomonic severe behaviors. The clinically optimized screener demonstrated very good sensitively (87%) and specificity (81%) in regard to concurrent irritability-related DSM disorders. Modeling of the MAPS-TL-Youth-SR yielded similar results.
conclusionCharacterizing the normal: abnormal spectrum of irritability in preadolescence advances application of Research Domain Criteria methods to this developmental period. This foundational work yielded two developmentally specified tools for irritability characterization in preadolescence: a nuanced dimensional scale to precisely characterize the full normal-abnormal irritability spectrum, and a pragmatic, clinically optimized screener suitable for real world use. Future application in mechanistic and clinical studies will be important for establishing validity and incremental utility.
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