ArticleClinical and experimental immunology1986
Individual variation of anti-Sm autoantibodies in the MRL/MP-lpr/lpr mouse: age-related increase in diversity.
Article in Clinical and experimental immunology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Further characterization of the autoantibody response of Palmerston North mice.Journal of clinical immunology · 1999Article
- Anti-Sm autoantibodies in systemic lupus erythematosus mice: a model system for disease-specific autoreactivity.Springer seminars in immunopathology · 1992Review
- Analysis of immunoglobulins secreted by hybridomas derived from rheumatoid synovia.Clinical and experimental immunology · 1990Article
- Rapid clearance of the lupus antigen Sm is delayed by autoantibody: a possible mechanism of autoimmunity perpetuation.Clinical and experimental immunology · 1989Article
- Relationship of age and sex to autoantibody expression in MRL-+/+ and MRL-lpr/lpr mice: demonstration of an association between the expression of antibodies to histones, denatured DNA and Sm in MRL-+/+ mice.Clinical and experimental immunology · 1988Article
- Anti-nRNP anti-nuclear antibody-secreting cells are represented in the B-lymphocyte repertoire of normal and MRL/MP-lpr/lpr lupus mice.Immunology · 1988Article
- Differential induction of lupus associated antinuclear antibodies in MRL mice by monoclonal anti-Sm antibodies.Clinical and experimental immunology · 1987Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence and diversity of anti-Sm antibodies (which are a marker of human lupus) were investigated in MRL/MP-lpr/lpr mice. The low prevalence of anti-Sm reported by other workers was confirmed. Anti-Sm antibodies bound to either the 28 kD or both 28 and 16 kD polypeptides on immunoblots. Antibodies to the 16 kD polypeptide, detected on spectrotyping blots, were not detected on immunoblots probed with sera from three mice, suggesting that these antibodies were binding only to an additional conformational epitope. Isoelectric focusing of the sera showed that the anti-Sm antibodies were restricted in clonal diversity and in some cases resembled the pattern of a monoclonal antibody. A longitudinal increase in antibody titre was correlated in some mice with an increase in the diversity of clones expressing anti-Sm antibody. Anti-nRNP antibodies were also detected in the mouse serum but had a lower prevalence than anti-Sm antibodies.
Indexed as
Identifiers
3780041PMC1542507W650537What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.