Trial reportStroke2023
Transport Strategy in Patients With Suspected Acute Large Vessel Occlusion Stroke: TRIAGE-STROKE, a Randomized Clinical Trial.
Trial report in Stroke, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03542188 (TReatment Strategy In Acute Ischemic larGE Vessel STROKE), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TReatment Strategy In Acute Ischemic larGE Vessel STROKE: Prioritize Thrombolysis or Endovascular Treatment
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mothership Versus Drip-and-Ship Models in Acute Stroke Care: A Time-Sensitive Meta-Analysis.Journal of the American Heart Association · 2026Pooled it
- Early Recognition and Referral of Acute Stroke in Primary and Emergency Care: A Systematic Review.The western journal of emergency medicine · 2026Pooled it
- Effects of Add-On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial.Annals of clinical and translational neurology · 2026Article
- EDEN - Enhanced Dispatch for Efficient Neurointervention: mathematical model from national data.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Integrated drip-and-ship improves stroke transfer efficiency and outcomes: a comparison with traditional drip-and-ship and mothership models.Journal of neurointerventional surgery · 2026Article
- Article
- Direct Transport to a Thrombectomy Center Accelerates Acute Stroke Reperfusion Therapies in Nonurban Settings.Journal of the American Heart Association · 2026Observational
- Reducing onset-to-door times through the implementation of a prehospital large vessel occlusion bypass protocol: the Oahu experience.Frontiers in stroke · 2026Article
- The burden and management of emergency room neurological consultation in hub and spoke Italian hospitals: the nationwide surveys of the Italian Association for Emergency Neurology (ANEU).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Natural language processing for triage of cerebral large-vessel occlusion.Arquivos de neuro-psiquiatria · 2025Article
- Direct-to-Angio Without Any Repeat Neuroimaging for Planned Endovascular Therapy in Patients Transferred From Remote Primary Stroke Centers: A Propensity-Matched Study.Stroke (Hoboken, N.J.) · 2025Article
- A Transfer Strategy Utilizing a Helicopter and a Ground Ambulance Together Does Not Prolong Door-In-Door-Out Times in Thrombectomy Patients: A Retrospective Analysis.European journal of neurology · 2025Article
- Thrombectomy Selection in the Large Core Era: Implications for Regional Transfers.Current neurology and neuroscience reports · 2025Review
- Review
- Impact of the drip-and-ship model on the treatment of acute ischemic stroke in relation to distance from the thrombectomy center.Frontiers in neurology · 2025Article
- Drip and ship in patients with acute ischemic stroke: a narrative review.Therapeutic advances in neurological disorders · 2025Review
- Patients with acute intracerebral hemorrhage and severe symptoms are highly sensitive to prehospital delay. A subgroup analysis from the RESIST and TRIAGE-STROKE trials.Frontiers in stroke · 2024Article
- A narrative review of reperfusion therapy in acute ischemic stroke: Emerging advances, current challenges, and future directions.Brain circulationReview
- Influence of interhospital transfer on endovascular thrombectomy outcome in acute ischemic stroke patients: an analysis of the TREAT-AIS registry.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhen patients with acute ischemic stroke present with suspected large vessel occlusion in the catchment area of a primary stroke center (PSC), the benefit of direct transport to a comprehensive stroke center (CSC) has been suggested. Equipoise remains between transport strategies and the best transport strategy is not well established.
methodsWe conducted a national investigator-driven, multicenter, randomized, assessor-blinded clinical trial. Patients eligible for intravenous thrombolysis (IVT) who were suspected for large vessel occlusion were randomized 1:1 to admission to the nearest PSC (prioritizing IVT) or direct CSC admission (prioritizing endovascular therapy). The primary outcome was functional improvement at day 90 for all patients with acute ischemic stroke, measured as shift towards a lower score on the modified Rankin Scale score.
resultsFrom September 2018 to May 2022, we enrolled 171 patients of whom 104 had acute ischemic stroke. The trial was halted before full recruitment. Baseline characteristics were well balanced. Primary analysis of shift in modified Rankin Scale (ordinal logistic regression) revealed an odds ratio for functional improvement at day 90 of 1.42 (95% CI, 0.72-2.82,
conclusionsThis trial investigated the benefit of bypassing PSC. We included only IVT-eligible patients presenting <4 hours from onset and with suspected large vessel occlusion. Lack of power prevented the results from showing effect on functional outcome for patients going directly to CSC. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT03542188.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.