Evidence map›Paper›PMID 37800334›Full record

ArticleCirculation research2023

Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of

Duan Liu, Min Wang, Vishakantha Murthy, Dennis M McNamara, Thanh Thanh L Nguyen, Trudy J Philips, Hridyanshu Vyas, Huanyao Gao, Jyotan Sahni, Randall C Starling and 17 more

Open access · greenAbstract read
In one paragraph

Article in Circulation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Proteogenomic Analysis of Coronary Artery Calcification in Human Populations.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Article
  2. Review
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  4. Article
  5. Review
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  7. Article
  8. Article
  9. Review
  10. Article
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  12. Methylations in dilated cardiomyopathy and heart failure.Frontiers in cardiovascular medicine · 2025
    Review
  13. Myocardial Recovery and Relapse in Heart Failure With Improved Ejection Fraction.Current treatment options in cardiovascular medicine · 2024
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 10 institutions in 4 countries.

Duan Liu *Departments of Molecular Pharmacology and Experimental Therapeutics (D.L., V.M., T.T.L.N., T.J.P., H.G., R.M.W., N.L.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0003-1065-246X
Min Wang *Cardiovascular Medicine (M.W., V.M., H.V., J.S., N.L.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0001-6759-9132
Vishakantha MurthyDepartments of Molecular Pharmacology and Experimental Therapeutics (D.L., V.M., T.T.L.N., T.J.P., H.G., R.M.W., N.L.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0003-3279-5322
Dennis M McNamaraDepartment of Medicine, University of Pittsburgh, PA (D.M.M.).
Thanh Thanh L NguyenDepartments of Molecular Pharmacology and Experimental Therapeutics (D.L., V.M., T.T.L.N., T.J.P., H.G., R.M.W., N.L.P.), Mayo Clinic, Rochester, MN.
Trudy J PhilipsDepartments of Molecular Pharmacology and Experimental Therapeutics (D.L., V.M., T.T.L.N., T.J.P., H.G., R.M.W., N.L.P.), Mayo Clinic, Rochester, MN.
Hridyanshu VyasCardiovascular Medicine (M.W., V.M., H.V., J.S., N.L.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-1929-1341
Huanyao GaoDepartments of Molecular Pharmacology and Experimental Therapeutics (D.L., V.M., T.T.L.N., T.J.P., H.G., R.M.W., N.L.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-9441-9579
Jyotan SahniCardiovascular Medicine (M.W., V.M., H.V., J.S., N.L.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0002-7038-1190
Randall C StarlingDepartment of Cardiovascular Medicine, Cleveland Clinic, OH (R.C.S.).ORCID 0000-0002-1254-4860
Leslie T CooperDepartment of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL (L.T.C.).ORCID 0000-0003-1002-3313
Michelle K SkimePsychiatry and Psychology (M.K.S.), Mayo Clinic, Rochester, MN.ORCID 0000-0001-7863-3017
Anthony BatzlerHealth Sciences Research (A.B., G.D.J.), Mayo Clinic, Rochester, MN.ORCID 0000-0003-3753-4930
Gregory D JenkinsHealth Sciences Research (A.B., G.D.J.), Mayo Clinic, Rochester, MN.
Simona BarleraDepartment of Cardiovascular Research, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy (S.B., S.P.).
Silvana PileggiDepartment of Cardiovascular Research, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy (S.B., S.P.).ORCID 0000-0002-4306-9476
Luisa MestroniDivision of Cardiology, Department of Medicine, Cardiovascular Institute, University of Colorado School of Medicine, Aurora (L.M.).ORCID 0000-0003-1116-2286
Marco MerloCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Italy (M.M., G.S.).
Gianfranco SinagraCardiothoracovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, University of Trieste, Italy (M.M., G.S.).ORCID 0000-0003-2700-8478
Florence PinetPôle Cardio-vasculaire et Pulmonaire, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, France (F.P., P.d.G.).ORCID 0000-0002-5471-1487
Jan KrejčíFirst Department of Internal Medicine, Cardiology and Angiology, St. Anne's University Hospital and Masaryk University, Brno, Czech Republic (J.K., A.C.).ORCID 0000-0003-4468-2843
Anna ChaloupkaFirst Department of Internal Medicine, Cardiology and Angiology, St. Anne's University Hospital and Masaryk University, Brno, Czech Republic (J.K., A.C.).ORCID 0000-0001-7734-474X
Jordan D MillerCardiovascular Surgery (J.D.M.), Mayo Clinic, Rochester, MN.
Pascal de GrootePôle Cardio-vasculaire et Pulmonaire, University Lille, Inserm, CHU Lille, Institut Pasteur de Lille, France (F.P., P.d.G.).ORCID 0000-0002-6211-0147
Daniel J TschumperlinPhysiology and Biomedical Engineering (D.J.T.), Mayo Clinic, Rochester, MN.
Richard M WeinshilboumDepartments of Molecular Pharmacology and Experimental Therapeutics (D.L., V.M., T.T.L.N., T.J.P., H.G., R.M.W., N.L.P.), Mayo Clinic, Rochester, MN.
Naveen L PereiraDepartments of Molecular Pharmacology and Experimental Therapeutics (D.L., V.M., T.T.L.N., T.J.P., H.G., R.M.W., N.L.P.), Mayo Clinic, Rochester, MN.ORCID 0000-0003-3813-3469
Mayo Clinic · USAzienda Sanitaria Universitaria Integrata di Trieste · ITInserm · FRMario Negri Institute for Pharmacological Research · ITMasaryk University · CZMayo Clinic in Florida · USCleveland Clinic · USJacksonville College · USUniversity of Colorado Denver · USUniversity of Pittsburgh · US

Funding

Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic CardiomyopathyR01HL116906 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MARCUS, FRANK I, MESTRONI, LUISA · 2013 to 2016
$9.2M
TRAINING GRANT IN CLINICAL PHARMACOLOGYT32GM008685 · NIGMS · MAYO CLINIC ROCHESTER · PI Liewei Wang · 1998 to 2026
$8.2M
Engineering Cardiac spheroids to study LaminopathiesR01HL164634 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Luisa Mestroni, Matthew R Taylor · 2023 to 2026
$2.8M
Molecular Epidemiology of Dilated CardiomyopathR01HL069071 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MESTRONI, LUISA · 2002 to 2005
$2.3M
Genetic Modulation of Left Ventricular RecoveryR01HL075038 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCNAMARA, DENNIS M. · 2004 to 2008
$1.8M
NHLBI NIH HHS R01 HL069071NHLBI NIH HHS R01 HL075038NHLBI NIH HHS R01 HL116906NHLBI NIH HHS R01 HL164634NIGMS NIH HHS T32 GM008685
6 · The paper itself

Abstract

backgroundDilated cardiomyopathy (DCM) is a major cause of heart failure and carries a high mortality rate. Myocardial recovery in DCM-related heart failure patients is highly variable, with some patients having little or no response to standard drug therapy. A genome-wide association study may agnostically identify biomarkers and provide novel insight into the biology of myocardial recovery in DCM.

methodsA genome-wide association study for change in left ventricular ejection fraction was performed in 686 White subjects with recent-onset DCM who received standard pharmacotherapy. Genome-wide association study signals were subsequently functionally validated and studied in relevant cellular models to understand molecular mechanisms that may have contributed to the change in left ventricular ejection fraction.

resultsThe genome-wide association study identified a highly suggestive locus that mapped to the 5'-flanking region of the

conclusions

Indexed as

Cardiomyopathy, DilatedHeart FailureAntigens, NeoplasmCell Adhesion MoleculesFibrosisGenome-Wide Association StudyHumansStroke VolumeVentricular Function, LeftAntigens, NeoplasmCDCP1 protein, humanCell Adhesion Moleculescardiomyopathy, dilatedfibrosisgeneticsgenome-wide association studyheart failurehumansventricular remodeling

Identifiers

PMID37800334
PMCPMC10746262
OpenAlexW4387392967

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.