Evidence map›Paper›PMID 37800277›Full record

ArticleProtein science : a publication of the Protein Society2023

Identification and characterization of a small molecule that activates thiosulfate sulfurtransferase and stimulates mitochondrial respiration.

Zeyana M Al-Dahmani, Mojgan Hadian, Angel J Ruiz-Moreno, Sabogal-Guaqueta Angelica Maria, Fernando A Batista, Ran Zhang, Yang Luo, Afsaneh Sadremomtaz, Robin van der Straat, Mette Spoor and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Zeyana M Al-DahmaniDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.ORCID 0000-0001-8860-4404
Mojgan HadianDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.
Angel J Ruiz-MorenoDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.
Sabogal-Guaqueta Angelica MariaDepartment of Pharmacy, Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
Fernando A BatistaDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.
Ran ZhangDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.
Yang LuoDepartment of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands.
Afsaneh SadremomtazDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.
Robin van der StraatDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.
Mette SpoorDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.
Amalia M DolgaDepartment of Pharmacy, Molecular Pharmacology, University of Groningen, Groningen, The Netherlands.
Frank J DekkerDepartment of Pharmaceutical Gene Modulation, University of Groningen, Groningen, The Netherlands.
Alexander Dömling S SDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.
Harry van GoorDepartment of Pathology and Medical Biology, University Medical Center Groningen, Groningen, The Netherlands.
Matthew R GrovesDepartment of Pharmacy and Drug Design, University of Groningen, Groningen, The Netherlands.
University of Groningen · NLUniversity Medical Center Groningen · NLInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enzyme Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), is a positive genetic predictor of diabetes type 2 and obesity. As increased TST activity protects against the development of diabetic symptoms in mice, an activating compound for TST may provide therapeutic benefits in diabetes and obesity. We identified a small molecule activator of human TST through screening of an inhouse small molecule library. Kinetic studies in vitro suggest that two distinct isomers of the compound are required for full activation as well as an allosteric mode of activation. Additionally, we studied the effect of TST protein and the activator on TST activity through mitochondrial respiration. Molecular docking and molecular dynamics (MD) approaches supports an allosteric site for the binding of the activator, which is supported by the lack of activation in the Escherichia coli. mercaptopyruvate sulfurtransferase. Finally, we show that increasing TST activity in isolated mitochondria increases mitochondrial oxygen consumption.

Indexed as

Diabetes MellitusThiosulfate SulfurtransferaseAnimalsHumansKineticsMiceMitochondriaMolecular Docking SimulationObesityRespirationThiosulfate Sulfurtransferasediabetesmitochondriathiosulfate sulfurtransferase

Identifiers

PMID37800277
PMCPMC10594923
OpenAlexW4387392214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.