Evidence map›Paper›PMID 37800272›Full record

ArticlePediatrics2023

Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda.

Martina Knappett, Anneka Hooft, Muhammad Bilal Maqsood, Pascal M Lavoie, Teresa Kortz, Sonia Mehta, Jessica Duby, Samuel Akech, Michuki Maina, Rebecca Carter and 19 more

Open access · greenAbstract read
In one paragraph

Article in Pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 15 institutions in 6 countries.

Martina KnappettInstitute for Global Health, British Columbia Children's & Women's Hospital, Vancouver, Canada.
Anneka HooftDepartment of Emergency Medicine.
Muhammad Bilal MaqsoodDivision of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, Canada.
Pascal M LavoieDivision of Neonatology, Department of Pediatrics, University of British Columbia, Vancouver, Canada.
Teresa KortzDivision of Critical Care, Department of Pediatrics.
Sonia MehtaDepartment of Emergency Medicine.
Jessica DubyDepartment of Pediatrics, McGill University, Montreal, Canada.
Samuel AkechKenya Medical Research Institute/Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
Michuki MainaHealth Services Research Group, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.
Rebecca CarterDivision of Neonatology, Department of Pediatrics, University of California San Diego, La Jolla, California.
Constantin R PopescuBritish Columbia Children's Hospital Research Institute, Vancouver, Canada.
Rajesh DaftaryDepartment of Pediatrics.
Nathan Kenya MugishaWalimu, Kampala, Uganda.
Douglas MwesigwaMbarara University of Science and Technology, Mbarara, Uganda.
Jerome KabakyengaDepartment of Community Health.
Elias KumbakumbaDepartment of Pediatrics and Child Health, Mbarara University of Science and Technology, Mbarara, Uganda.
J Mark AnserminoInstitute for Global Health, British Columbia Children's & Women's Hospital, Vancouver, Canada.
Niranjan KissoonInstitute for Global Health, British Columbia Children's & Women's Hospital, Vancouver, Canada.
Andrew MutekangaMbarara University of Science and Technology, Mbarara, Uganda.
Duncan HauDepartment of Pediatrics, Weill Cornell Medical College, New York, New York.
Peter MoschovisDivision of Global Health, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts.
Mukuka KangwaDepartment of Emergency Medicine.
Carol ChenDepartment of Emergency Medicine.
Maytal FirnbergDepartment of Emergency Medicine.
Nicolaus GlombDepartment of Emergency Medicine.
Andrew ArgentDepartment of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa.
Stephen J ReidDepartment of Family, Community and Emergency Care, University of Cape Town, Cape Town, South Africa.
Adnan BhuttaDivision of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
Matthew O WiensInstitute for Global Health, British Columbia Children's & Women's Hospital, Vancouver, Canada.
Pediatrics and Genetics · USMbarara University of Science and Technology · UGUniversity of British Columbia · CABC Children's Hospital · CAChildren's & Women's Health Centre of British Columbia · CAKenya Medical Research Institute · KEUniversity of Cape Town · ZACornell University · USGlobal Brain Health Institute · USHarvard University · USIndiana University – Purdue University Indianapolis · USInstitute for Community Health · USMcGill University · CARoyal College of Emergency Medicine · GBUniversity of California San Diego · US

Funding

The effect of household air pollution on lung function growth in infants with pneumonia in sub-Saharan Africa.K23ES030399 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSCHOVIS, PETER P · 2019 to 2024
$1.1M
Fever Etiology and Prognostic Point-of-Care Biomarkers in African Children with Severe Febrile IllnessK23AI144029 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTZ, TERESA · 2020 to 2024
$984k
NIAID NIH HHS K23 AI144029NIEHS NIH HHS K23 ES030399
6 · The paper itself

Abstract

backgroundReducing child mortality in low-income countries is constrained by a lack of vital statistics. In the absence of such data, verbal autopsies provide an acceptable method to determining attributable causes of death. The objective was to assess potential causes of pediatric postdischarge mortality in children younger than age 5 years (under-5) originally admitted for suspected sepsis using verbal autopsies.

methodsSecondary analysis of verbal autopsy data from children admitted to 6 hospitals across Uganda from July 2017 to March 2020. Structured verbal autopsy interviews were conducted for all deaths within 6 months after discharge. Two physicians independently classified a primary cause of death, up to 4 alternative causes, and up to 5 contributing conditions using the Start-Up Mortality List, with discordance resolved by consensus.

resultsVerbal autopsies were completed for 361 (98.6%) of the 366 (5.9%) children who died among 6191 discharges (median admission age: 5.4 months [interquartile range, 1.8-16.7]; median time to mortality: 28 days [interquartile range, 9-74]). Most deaths (62.3%) occurred in the community. Leading primary causes of death, assigned in 356 (98.6%) of cases, were pneumonia (26.2%), sepsis (22.1%), malaria (8.5%), and diarrhea (7.9%). Common contributors to death were malnutrition (50.5%) and anemia (25.7%). Reviewers were less confident in their causes of death for neonates than older children (P < .05).

conclusionsPostdischarge mortality frequently occurred in the community in children admitted for suspected sepsis in Uganda. Analyses of the probable causes for these deaths using verbal autopsies suggest potential areas for interventions, focused on early detection of infections, as well as prevention and treatment of underlying contributors such as malnutrition and anemia.

Indexed as

AnemiaMalnutritionSepsisAdolescentAftercareAutopsyCause of DeathChildChild, PreschoolHumansInfantInfant, NewbornPatient DischargeUganda

Identifiers

PMID37800272
PMCPMC11006254
OpenAlexW4387392755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.