Evidence map›Paper›PMID 37799760›Full record

ReviewNeurophotonics2023

Characterizing the blood-brain barrier and gut barrier with super-resolution imaging: opportunities and challenges.

Ellen Doney, Renaud Bernatchez, Valérie Clavet-Fournier, Katarzyna A Dudek, Laurence Dion-Albert, Flavie Lavoie-Cardinal, Caroline Menard

Abstract readReview
In one paragraph

Review in Neurophotonics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ellen DoneyUniversité Laval, Department of Psychiatry and Neuroscience, Faculty of Medicine, Quebec City, Québec, Canada.ORCID https://orcid.org/0000-0003-2094-5514
Renaud BernatchezCERVO Brain Research Center, Québec City, Québec, Canada.
Valérie Clavet-FournierCERVO Brain Research Center, Québec City, Québec, Canada.
Katarzyna A DudekUniversité Laval, Department of Psychiatry and Neuroscience, Faculty of Medicine, Quebec City, Québec, Canada.ORCID https://orcid.org/0000-0003-4894-5268
Laurence Dion-AlbertUniversité Laval, Department of Psychiatry and Neuroscience, Faculty of Medicine, Quebec City, Québec, Canada.ORCID https://orcid.org/0000-0002-7051-6390
Flavie Lavoie-CardinalUniversité Laval, Department of Psychiatry and Neuroscience, Faculty of Medicine, Quebec City, Québec, Canada.
Caroline MenardUniversité Laval, Department of Psychiatry and Neuroscience, Faculty of Medicine, Quebec City, Québec, Canada.ORCID https://orcid.org/0000-0001-8202-7378

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain and gut barriers have been receiving increasing attention in health and diseases including in psychiatry. Recent studies have highlighted changes in the blood-brain barrier and gut barrier structural properties, notably a loss of tight junctions, leading to hyperpermeability, passage of inflammatory mediators, stress vulnerability, and the development of depressive behaviors. To decipher the cellular processes actively contributing to brain and gut barrier function in health and disease, scientists can take advantage of neurophotonic tools and recent advances in super-resolution microscopy techniques to complement traditional imaging approaches like confocal and electron microscopy. Here, we summarize the challenges, pros, and cons of these innovative approaches, hoping that a growing number of scientists will integrate them in their study design exploring barrier-related properties and mechanisms.

Indexed as

algorithmsstimulated emission depletionstochastic optical reconstruction microscopytight junctions

Identifiers

PMID37799760
PMCPMC10548114

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.