Evidence map›Paper›PMID 37799698›Full record

ArticleBiomedical optics express2023

Microrheology and structural quantification of hypercoagulable clots.

Laura Wolff-Trombini, Adrien Ceripa, Julien Moreau, Hubert Galinat, Chloe James, Nathalie Westbrook, Jean-Marc Allain

Abstract read
In one paragraph

Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Deconstructing fibrin(ogen) structure.Journal of thrombosis and haemostasis : JTH · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura Wolff-TrombiniUniversité de Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, Pessac, France.
Adrien CeripaLMS, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, Palaiseau, France.
Julien MoreauUniversité Paris-Saclay, Institut d'Optique Graduate School, CNRS, Laboratoire Charles Fabry, Palaiseau, France.
Hubert GalinatCHU de Brest, Service d'Hématologie Biologique, Brest, France.
Chloe JamesUniversité de Bordeaux, UMR1034, Inserm, Biology of Cardiovascular Diseases, Pessac, France.
Nathalie WestbrookUniversité Paris-Saclay, Institut d'Optique Graduate School, CNRS, Laboratoire Charles Fabry, Palaiseau, France.
Jean-Marc AllainLMS, CNRS, Ecole Polytechnique, Institut Polytechnique de Paris, Palaiseau, France.ORCID https://orcid.org/0000-0002-5273-7739

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypercoagulability is a pathology that remains difficult to explain today in most cases. It is likely due to a modification of the conditions of polymerization of the fibrin, the main clot component. Using passive microrheology, we measured the mechanical properties of clots and correlated them under the same conditions with structural information obtained with confocal microscopy. We tested our approach with known alterations: an excess of fibrinogen and of coagulation Factor VIII. We observed simultaneously a rigidification and densification of the fibrin network, showing the potential of microrheology for hypercoagulability diagnosis.

Identifiers

PMID37799698
PMCPMC10549726

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.