Evidence map›Paper›PMID 37799472›Full record

ReviewFrontiers in oncology2023

Nanotube breakthroughs: unveiling the potential of carbon nanotubes as a dual therapeutic arsenal for Alzheimer's disease and brain tumors.

Deena Elsori, Gowhar Rashid, Nihad Ashraf Khan, Punya Sachdeva, Riya Jindal, Falak Kayenat, Bhuvi Sachdeva, Mohammad Azhar Kamal, Asaad Ma Babker, Sherif Ashraf Fahmy

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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  13. Carbon nanotubes as neuroprotective agents.Exploration of neuroprotective therapy · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 3 countries.

Deena ElsoriFaculty of Resillience, Deans Office Rabdan Academy, Abu Dhabi, United Arab Emirates.
Gowhar RashidAmity Medical School, Amity University Gurgaon, Haryana, India.
Nihad Ashraf KhanDepartment of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India.
Punya SachdevaDepartment of Neuropyschology and Neurosciences, Amity University, Noida, UP, India.
Riya JindalDepartment of Biotechnology, Shoolini University, Himachal Pradesh, India.
Falak KayenatDepartment of Biotechnology, Jamia Hamdard University, New Delhi, India.
Bhuvi SachdevaDepartment of Physics and Astrophysics, Bhagini Nivedita College, University of Delhi, New Delhi, India.
Mohammad Azhar KamalDepartment of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Asaad Ma BabkerDepartment of Medical Laboratory Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Sherif Ashraf FahmyDepartment of Chemistry, School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, Cairo, Egypt.
Amity University · INGulf Medical University · AEJamia Hamdard · INJamia Millia Islamia · INPrince Sattam Bin Abdulaziz University · SAShoolini University · INUniversity of Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) and brain tumors are debilitating neurological conditions that pose significant challenges in current medical practices. Existing treatment options for AD primarily focus on symptom management, and brain tumors often require aggressive therapeutic approaches. Novel disease-modifying strategies and therapeutic agents are urgently needed to address the underlying causes of AD pathogenesis and improve brain tumor management. In recent years, nanoparticles (NPs) have shown promise as valuable tools in diagnosing and managing various brain disorders, including AD. Among these, carbon nanotubes (CNTs) have garnered attention for their unique properties and biomedical potential. Their ability to cross the blood-brain barrier (BBB) with ease opens up new possibilities for targeted drug delivery and neuroprotection. This literature review aims to explore the versatile nature of CNTs, which can be functionalized with various biomolecules or substances due to their sp2 hybridization. This adaptability enables them to specifically target cells and deliver medications under specific environmental conditions. Moreover, CNTs possess an exceptional capacity to penetrate cell membranes, making them valuable tools in the treatment of AD and brain tumors. By delving into the role of CNTs in biomedicine, this review sheds light on their potential in managing AD, offering a glimpse of hope for effective disease-modifying options. Understanding the mechanisms of CNTs' action and their capabilities in targeting and delivering medication to affected cells will pave the way for innovative therapeutic strategies that can improve the lives of those afflicted with these devastating neurological conditions. The exploration of CNTs as a dual therapeutic arsenal for both brain tumors and Alzheimer's disease holds great promise and may usher in a new era of effective treatment strategies for these challenging conditions.

Indexed as

Alzheimer’s diseasebrain tumorcarbon nanotubesnanoparticlesnanotubes

Identifiers

PMID37799472
PMCPMC10548133
OpenAlexW4386931830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.