ReviewJournal of children's orthopaedics2023
Epidemiology, natural evolution, pathogenesis, clinical spectrum, and management of Legg-Calvé-Perthes.
Review in Journal of children's orthopaedics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The MTHFR C677T polymorphism and protection against Legg-Calvé-Perthes disease in children: an updated systematic review and meta-analysis.Orphanet journal of rare diseases · 2026Pooled it
- Role of Non-Coding RNAs in Pathogenesis, Diagnosis, and Therapy of Legg-Calvé-Perthes Disease: A Systematic Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Pooled it
- Association of ligamentum teres thickness on MRI with femoral head extrusion in Legg-Calvé-Perthes disease.Skeletal radiology · 2026Article
- Patient-Derived iPSC-MSC Modelling Reveals Reversible GSK3-Mediated Suppression of Mesenchymal Lineage Differentiation in Legg-Calvé-Perthes Disease.Journal of cellular and molecular medicine · 2026Article
- Nationwide Epidemiological and Demographic Evolution of Legg-Calvé-Perthes Disease: A 10-Year Analysis.Journal of the Pediatric Orthopaedic Society of North America · 2026Article
- Determination of Modified Waldenström Staging in Legg-Calvé-Perthes Disease Using Deep Learning.Journal of the Pediatric Orthopaedic Society of North America · 2026Article
- Article
- Legg-Calve-Perthes disease: an idiopathic avascular necrosis of the femoral head with an Eponym. A review through the higher exams candidate's eyes.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Review
- Psychometric evaluation and adaptability of the simplified Chinese version of HOOS-12 in patients undergoing total hip arthroplasty.Health and quality of life outcomes · 2026Article
- Long-term radiographic outcomes following containment surgery for Legg-Calvé-Perthes disease in the reossification stage.Frontiers in pediatrics · 2026Article
- Femoral head vascular status in early-stage Legg-Calvé-Perthes disease assessed by contrast-enhanced magnetic resonance imaging: comparison with the contralateral side.Orphanet journal of rare diseases · 2025Article
- Radiographic and functional outcomes of shelf acetabuloplasty versus conservative management in legg-calvé-perthes disease: an age- and gender-matched study including healthy controls for isokinetic hip muscle strength.International orthopaedics · 2025Article
- Adaptation and psychometric evaluation of the Chinese version of the hip disability and osteoarthritis outcome Score-Physical function Short-form (HOOS-PS).BMC musculoskeletal disorders · 2025Article
- Biochanin A enhances type H vessel formation and improves epiphysis deformities following ischemic osteonecrosis in juvenile mouse.Frontiers in nutrition · 2025Article
- Article
- LOCAL INJECTION OF HUMAN DENTAL PULP STEM CELLS FOR TREATMENT OF JUVENILE AVASCULAR NECROSIS OF THE FEMORAL HEAD: PRELIMINARY RESULTS IN IMMATURE PIGS.Acta ortopedica brasileira · 2025Article
- Diagnosis and Management of Legg-Calvé-Perthes Disease in the Obese Pediatric Population.Journal of orthopedics for physician assistantsArticle
- Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head.Journal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Legg-Calvé-Perthes disease is a self-limiting disorder that develops in children following interruption of the blood supply to the capital femoral epiphysis. This review outlines the current knowledge on the epidemiology, natural evolution, clinical spectrum, and management of the disease. Methods: The literature pertaining to these aspects of the disease were studied and summarized in this review. Results: Epidemiological studies suggest that environmental factors contribute to the causation of the disease. Incidence rates monitored over time indicate that the incidence of Legg-Calvé-Perthes disease is declining. The natural evolution followed on sequential plain radiographs enables division of the disease into Stages Ia, Ib, IIa, IIb, IIIa, IIIb, and IV. Reversible deformation of the capital occurs in Stages Ia-IIa simply on standing while irreversible deformation may occur in Stages IIb and IIIa. Treatment of Legg-Calvé-Perthes disease in Stages Ia-IIa aims to prevent the femoral head from getting deformed by containment and avoidance of weight-bearing. In Stages IIb and IIIa, treatment aims to remedy the effects of early irreversible deformation of the femoral head. In Stage IIIb and IV, treatment is directed to correcting the altered shape of the femoral head. The impression that these treatment methods are helpful is based on poor quality evidence. Conclusion: There is an urgent need to undertake Level I studies to establish the efficacy of currently treatment. Level of evidence: level V.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.