Evidence map›Paper›PMID 37798969›Full record

ArticleNeurospine2023

Clinical Characteristics and Long-term Outcomes of Spinal Pilocytic Astrocytomas: A Multicenter Retrospective Study by the Neurospinal Society of Japan.

Jun Muto, Hidetoshi Murata, Seiji Shigekawa, Takafumi Mitsuhara, Daisuke Umebayashi, Ryo Kanematsu, Masahiro Joko, Tatsushi Inoue, Tomoo Inoue, Toshiki Endo and 2 more

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Article in Neurospine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jun MutoDepartment of Neurosurgery, Fujita Health University, Aichi, Japan.
Hidetoshi MurataDepartment of Neurosurgery, St. Marianna University School of Medicine, Yokohama, Japan.
Seiji ShigekawaDepartment of Neurosurgery, Ehime University, Ehime, Japan.
Takafumi MitsuharaDepartment of Neurosurgery, Hiroshima University, Hiroshima, Japan.
Daisuke UmebayashiDepartment of Neurosurgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Ryo KanematsuDepartment of Spinal Disorders Center, Fujieda Heisei Memorial Hospital, Shizuoka, Japan.
Masahiro JokoDepartment of Neurosurgery, Fujita Health University, Aichi, Japan.
Tatsushi InoueDepartment of Neurosurgery, Fujita Health University, Aichi, Japan.
Tomoo InoueDepartment of Neurosurgery, Saitama Red Cross Hospital, Saitama, Japan.
Toshiki EndoDepartment of Neurosurgery, Tohoku Medical and Phamaceutical University, Sendai, Japan.
Yuichi HiroseDepartment of Neurosurgery, Fujita Health University, Aichi, Japan.
Investigators of Intramedullary Spinal Cord Tumors in the Neurospinal Society of Japan

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe characteristics, imaging features, long-term surgical outcomes, and recurrence rates of primary spinal pilocytic astrocytomas (PAs) have not been clarified owing to their rarity and limited reports. Thus, this study aimed to analyze the clinical presentation, radiological features, pathological findings, and long-term outcomes of spinal PAs.

methodsEighteen patients with spinal PAs who were surgically treated between 2009 and 2020 at 58 institutions were included in this retrospective multicenter study. Patient data, including demographics, radiographic features, treatment modalities, and long-term outcomes, were evaluated.

resultsAmong the 18 consecutive patients identified, 11 were women and 7 were men; the mean age at presentation was 31 years (3-73 years). Most PAs were located eccentrically, were solid or heterogeneous in appearance (cystic and solid), and had unclear margins. Gross total resection (GTR), subtotal resection (STR), partial resection (PR), and biopsy were performed in 28%, 33%, 33%, and 5% of cases, respectively. During a follow-up period of 65 ± 49 months, 4 patients developed a recurrence; however, the recurrence-free survival did not differ significantly between the GTR and non-GTR (STR, PR, and biopsy) groups.

conclusionPrimary spinal PAs are rare and present as eccentric and intermixed cystic and solid intramedullary cervical tumors. The imaging features of spinal PAs are nonspecific, and a definitive diagnosis requires pathological support. Surgical resection with prevention of neurological deterioration can serve as the first-line treatment; however, the resection rate does not affect recurrence-free survival. Investigation of relevant molecular biomarkers is required to elucidate the regrowth risk and prognostic factors.

Indexed as

Imaging featuresPilocytic astrocytomaPrognosisSpinal cord

Identifiers

PMID37798969
PMCPMC10562249

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