ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration2024
Non-motor symptoms in amyotrophic lateral sclerosis.
Article in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Uncovering hypothalamic network disruption in ALS.Journal of neurology · 2025Article
- Characteristics and influencing factors of pain in amyotrophic lateral sclerosis: a focus on symptom management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Magnetic Resonance Neuroimaging in Amyotrophic Lateral Sclerosis: A Comprehensive Umbrella Review of 18 Studies.Brain sciences · 2025Review
- The experience of pain symptoms in patients with amyotrophic lateral sclerosis: a qualitative study.Scientific reports · 2025Article
- Non-motor symptoms in patients with amyotrophic lateral sclerosis: current state and future directions.Journal of neurology · 2024Review
- Article
- Volume loss in the left anterior-superior subunit of the hypothalamus in amyotrophic lateral sclerosis.CNS neuroscience & therapeutics · 2024Article
- Analysis of non-motor symptoms in amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveWhile motor symptoms are well-known in ALS, non-motor symptoms are often under-reported and may have a significant impact on quality of life. In this study, we aimed to examine the nature and extent of non-motor symptoms in ALS.
methodsA 20-item questionnaire was developed covering the domains of autonomic function, sleep, pain, gastrointestinal disturbance, and emotional lability, posted online and shared on social media platforms to target people with ALS and controls.
resultsA total of 1018 responses were received, of which 927 were complete from 506 people with ALS and 421 unaffected individuals. Cold limbs (p 1.66 × 10
conclusionsNon-motor symptoms in ALS are common. The identification and management of non-motor symptoms should be integrated into routine clinical care for people with ALS. Further research is warranted to investigate the relationship between non-motor symptoms and disease progression, as well as to develop targeted interventions to improve the quality of life for people with ALS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.