Evidence map›Paper›PMID 37798677›Full record

ArticleAlzheimer's research & therapy2023

Cognitive impairment indicator for the neuropsychological test batteries in the Canadian Longitudinal Study on Aging: definition and evidence for validity.

Megan E O'Connell, Helena Kadlec, Lauren E Griffith, Christina Wolfson, Geva Maimon, Vanessa Taler, Susan Kirkland, Parminder Raina

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Case Reports in the Integration of Technology with Cognitive Rehabilitation for Individuals with Memory Concerns and Their Care Partners.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 1 country.

Megan E O'ConnellDepartment of Psychology and Health Studies, University of Saskatchewan, 9 Campus Drive, Arts 182, Saskatoon, SK, S7N 5A5, Canada. megan.oconnell@usask.ca.
Helena KadlecInstitute On Aging & Lifelong Health, University of Victoria, STN CSC, PO Box 1700, Victoria, BC, V8W 2Y2, Canada.
Lauren E GriffithDepartment of Health Research Methods, Evidence, and Impact, McMaster University, 175 Longwood Rd. S. Suite 309a, Hamilton, ON, L8P 0A1, Canada.
Christina WolfsonDepartment of Epidemiology and Biostatistics and Occupational Health, School of Population and Global Health, McGill University, 2001 McGill College Avenue Suite 1200, Montreal, QC, H3A 1G1, Canada.
Geva MaimonCLSA Data Curation Centre, Research Institute of the McGill University Health Centre, 2155 Guy Street, 4th Floor, Montreal, QC, H3H 2R9, Canada.
Vanessa TalerSchool of Psychology, University of Ottawa, 136 Jean Jacques Lussier, Vanier Hall, Ottawa, ON, K1N 6N5, Canada.
Susan KirklandDepartment of Community Health and Epidemiology, Dalhousie University, 5790 University Ave, Halifax, NS, B3H 1V7, Canada.
Parminder RainaDepartment of Health Research Methods, Evidence and Impact, Faculty of Health Sciences, McMaster Institute for Research On Aging & Labarge Centre for Mobility in Aging, McMaster University, MIP Suite 309A, 1280 Main St. W, Hamilton, ON, L8S 4K1, Canada.
Dalhousie University · CAImpact · CAMcGill University · CAMcGill University Health Centre · CAMcMaster University · CAUniversity of Ottawa · CAUniversity of Saskatchewan · CAUniversity of Victoria · CA

Funding

CIHR LSA 94473
6 · The paper itself

Abstract

backgroundPrevalence of overall cognitive impairment based on each participant's performance across a neuropsychological battery is challenging; consequently, we define and validate a dichotomous cognitive impairment/no cognitive indicator (CII) using a neuropsychological battery administered in a population-based study. This CII approximates the clinical practice of interpretation across a neuropsychological battery and can be applied to any neuropsychological dataset.

methodsUsing data from participants aged 45-85 in the Canadian Longitudinal Study on Aging receiving a telephone-administered neuropsychological battery (Tracking, N = 21,241) or a longer in-person battery (Comprehensive, N = 30,097), impairment was determined for each neuropsychological test based on comparison with normative data. We adjusted for the joint probability of abnormally low scores on multiple neuropsychological tests using baserates of low scores demonstrated in the normative samples and created a dichotomous CII (i.e., cognitive impairment vs no cognitive impairment). Convergent and discriminant validity of the CII were assessed with logistic regression analyses.

resultsUsing the CII, the prevalence of cognitive impairment was 4.3% in the Tracking and 5.0% in the Comprehensive cohorts. The CII demonstrated strong convergent and discriminant validity.

conclusionsThe approach for the CII is a feasible method to identify participants who demonstrate cognitive impairment on a battery of tests. These methods can be applied in other epidemiological studies that use neuropsychological batteries.

Indexed as

Cognitive DysfunctionAgingCanadaHumansLongitudinal StudiesNeuropsychological TestsBaseratesCLSACognitive impairment indicatorMeasurementMedical conditionsNeuropsychological batteryNormative data

Identifiers

PMID37798677
PMCPMC10552318
OpenAlexW4387369749

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.