Evidence map›Paper›PMID 37798648›Full record

ArticleBMC microbiology2023

Mycothiol maintains the homeostasis and signalling of nitric oxide in Streptomyces coelicolor A3(2) M145.

Tomoki Yoshizumi, Yukiko Shibui, Minori Kogo, Sota Honma, Shinsaku Ito, Shunsuke Yajima, Yasuyuki Sasaki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Tomoki YoshizumiDepartment of Bioscience, Faculty of Life Sciences, Tokyo University of Agriculture, Sakuragaoka, Tokyo, Setagaya-Ku, 156-8502, Japan.
Yukiko ShibuiDepartment of Bioscience, Faculty of Life Sciences, Tokyo University of Agriculture, Sakuragaoka, Tokyo, Setagaya-Ku, 156-8502, Japan.
Minori KogoDepartment of Bioscience, Faculty of Life Sciences, Tokyo University of Agriculture, Sakuragaoka, Tokyo, Setagaya-Ku, 156-8502, Japan.
Sota HonmaDepartment of Bioscience, Faculty of Life Sciences, Tokyo University of Agriculture, Sakuragaoka, Tokyo, Setagaya-Ku, 156-8502, Japan.
Shinsaku ItoDepartment of Bioscience, Faculty of Life Sciences, Tokyo University of Agriculture, Sakuragaoka, Tokyo, Setagaya-Ku, 156-8502, Japan.
Shunsuke YajimaDepartment of Bioscience, Faculty of Life Sciences, Tokyo University of Agriculture, Sakuragaoka, Tokyo, Setagaya-Ku, 156-8502, Japan.
Yasuyuki SasakiDepartment of Bioscience, Faculty of Life Sciences, Tokyo University of Agriculture, Sakuragaoka, Tokyo, Setagaya-Ku, 156-8502, Japan. y1sasaki@nodai.ac.jp.
Tokyo University of Agriculture · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have revealed a nitric oxide (NO) metabolic cycle in which NO, nitrate (NO

resultsTo investigate the interaction of MSH with endogenously produced NO, we generated an S. coelicolor A3(2) strain deficient in MSH biosynthesis. This mutant strain exhibited a decrease in low-molecular-weight S-nitrosothiols and intracellular NO levels during culture compared to those of the wild-type strain. Moreover, the mutant strain exhibited reduced activity of the DevS/DevR TCS, a regulator of NO homeostasis and ACT production, from the early stage of culture, along with a decrease in ACT production compared to those of the wild-type strain.

conclusionsThis study suggests that MSH maintains intracellular NO homeostasis by forming S-nitrosomycothiol, which induces NO signalling. Finally, we propose a metabolic model in which MSH from endogenously produced NO facilitates the maintenance of both NO homeostasis and signalling in S. coelicolor A3(2) M145.

Indexed as

Streptomyces coelicolorAnthraquinonesAnti-Bacterial AgentsBacterial ProteinsCysteineGene Expression Regulation, BacterialGlycopeptidesHomeostasisInositolNitric OxideAnthraquinonesAnti-Bacterial AgentsBacterial ProteinsCysteineGlycopeptidesInositolmycothiolNitric OxideActinobacteriaIntracellular homeostasisMycothiolNitric oxideSecondary metabolismSignal transduction

Identifiers

PMID37798648
PMCPMC10552308
OpenAlexW4387375376

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.