Evidence map›Paper›PMID 37798646›Full record

ArticleBMC research notes2023

The expression of matrix metalloproteinase 2, 9 and 11 in Ethiopian breast cancer patients.

Esmael Besufikad Belachew, Adey Feleke Desta, Dinikisira Bekele Deneke, Tewodros Yalew Gebremariam, Dessalegn Abeje Tefera, Fikadu Alemu Atire, Dawit Hailu Alemayehu, Tamirayehu Seyoum, Marcus Bauer, Selfu Girma and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Esmael Besufikad BelachewBiology Department, College of Natural and Computational Sciences, Mizan Tepi University, Mizan, Ethiopia. getbb2006@gmail.com.
Adey Feleke DestaDepartment of Microbial, Cellular and Molecular Biology, College of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Dinikisira Bekele DenekeArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Tewodros Yalew GebremariamDepartment of Pathology, School of Medicine, College of Health Science, Tikur Anbessa Specialized Hospital, Addis Ababa University, Addis Ababa, Ethiopia.
Dessalegn Abeje TeferaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Fikadu Alemu AtireArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Dawit Hailu AlemayehuArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Tamirayehu SeyoumArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Marcus BauerGlobal Health Working Group, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Selfu GirmaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Dareskedar Tsehay SewasewArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Eva J KantelhardtDepartment of Gynecology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Tesfaye Sisay TessemaInstitute of Biotechnology, Addis Ababa University, Addis Ababa, Ethiopia.
Rawleigh HoweArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Armauer Hansen Research Institute · ETAddis Ababa University · ETMartin Luther University Halle-Wittenberg · DEMizan Tepi University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMatrix metalloproteinases (MMPs) play a pathophysiological role in cancer initiation and progression. Numerous studies have examined an association between MMP-2, MMP-9, and MMP-11 expression and clinicopathological characteristics of breast cancer (BC); however, no research has been done on the MMP expression levels in BC cases from Ethiopia. MATERIALS AND

methodsA total of 58 formalin-fixed paraffin-embedded breast tissue samples encompassing 16 benign breast tumors and 42 BC were collected. The RNA was extracted and quantitative reverse-transcription PCR was performed. GraphPad Prism version 8.0.0 was used for statistical analysis.

resultsThe MMP-11 expression levels were significantly higher in breast cancer cases than in benign breast tumors (P = 0.012). Additionally, BC cases with positive lymph nodes and ER-positive receptors had higher MMP-11, MMP-9, and MMP-2 expression than cases with negative lymph nodes and ER-negative, respectively. The MMP-11 and MMP-9 expressions were higher in grade III and luminal A-like tumors than in grade I-II and other subtypes, respectively.

conclusionThe MMP-11 expression was higher in BC than in benign breast tumors. Additionally, MMP-11, MMP-9, and MMP-2 were higher in BC with positive lymph nodes and estrogen receptors. Our findings suggest an important impact of MMPs in BC pathophysiology, particularly MMP-11.

Indexed as

Breast NeoplasmsBiomarkers, TumorFemaleHumansMatrix Metalloproteinase 11Matrix Metalloproteinase 2Matrix Metalloproteinase 9Biomarkers, TumorMatrix Metalloproteinase 11Matrix Metalloproteinase 2Matrix Metalloproteinase 9BCBenign breast tumorEthiopiaMatrix metalloproteinasesmRNA expression

Identifiers

PMID37798646
PMCPMC10557335
OpenAlexW4387376351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.