Evidence map›Paper›PMID 37798615›Full record

ArticleGenome biology2023

GET_PANGENES: calling pangenes from plant genome alignments confirms presence-absence variation.

Bruno Contreras-Moreira, Shradha Saraf, Guy Naamati, Ana M Casas, Sandeep S Amberkar, Paul Flicek, Andrew R Jones, Sarah Dyer

Abstract read
In one paragraph

Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  4. Article
  5. Pangenomics in the Mimulus guttatus Species Complex.Molecular ecology resources · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bruno Contreras-MoreiraEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK. bcontreras@eead.csic.es.
Shradha SarafEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Guy NaamatiEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Ana M CasasEstación Experimental Aula Dei-CSIC, 50059, Zaragoza, Spain.
Sandeep S AmberkarInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Paul FlicekEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK.
Andrew R JonesInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Sarah DyerEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK. sdyer@ebi.ac.uk.ORCID http://orcid.org/0000-0001-5690-9633

Funding

Biotechnology and Biological Sciences Research Council BB/T015608/1Biotechnology and Biological Sciences Research Council BB/T015691/1Wellcome TrustWellcome Trust WT222155/Z/20/Z
6 · The paper itself

Abstract

Crop pangenomes made from individual cultivar assemblies promise easy access to conserved genes, but genome content variability and inconsistent identifiers hamper their exploration. To address this, we define pangenes, which summarize a species coding potential and link back to original annotations. The protocol get_pangenes performs whole genome alignments (WGA) to call syntenic gene models based on coordinate overlaps. A benchmark with small and large plant genomes shows that pangenes recapitulate phylogeny-based orthologies and produce complete soft-core gene sets. Moreover, WGAs support lift-over and help confirm gene presence-absence variation. Source code and documentation: https://github.com/Ensembl/plant-scripts .

Indexed as

Genome, PlantSoftwareCollinearityGene annotationPangenePlant genomePresence-absence variationWhole genome alignment

Identifiers

PMID37798615
PMCPMC10552430

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.