ArticleNature genetics2023
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.
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In one paragraph
Article in Nature genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
33.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects.Nature communications · 2026Pooled it
- Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting.Nature genetics · 2026Pooled it
- The influence of fetal sex on maternal blood pressure in pregnancy.BMC medicine · 2025Pooled it
- Update of the risk assessment on emerging and novel brominated flame retardants in food.EFSA journal. European Food Safety Authority · 2026Article
- Genetic and maternal environmental contributions to estimated fetal weight at 20 weeks gestation compared with birthweight.medRxiv : the preprint server for health sciences · 2026Article
- GWAS-by-subtraction reveals new genetic architecture and health implications of type 2 diabetes-independent gestational diabetes mellitus.Genome medicine · 2026Article
- Disentangling the relationship between intrauterine exposures and offspring growth in mid-childhood.BMC medicine · 2026Article
- Maternal health and autism risk: parsing direct and indirect genetic effects using 3-generation family linkage.medRxiv : the preprint server for health sciences · 2026Article
- A rapid review of genetic association studies of parent-of-origin effects and fetal growth.Molecular and cellular pediatrics · 2026Review
- 3D imaging of the pregnant uterus reveals an extensively invasive mouse placenta and early CXCL12-CXCR4 requirement.bioRxiv : the preprint server for biology · 2026Article
- Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes.Journal of global health · 2026Article
- Examining the association between fetal HLA-C, maternal KIR haplotypes and birth weight.PLoS genetics · 2026Article
- Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization.BMC medicine · 2026Article
- Genetics and Stillbirth.Clinics in perinatology · 2026Review
- A polygenic growth score and risk for large for gestational age birth weight.Journal of the Endocrine Society · 2026Article
- Utilizing offspring genotype-by-proxy Mendelian randomization to investigate the causal effect of offspring perinatal traits on maternal health.International journal of epidemiology · 2026Article
- Genomic approaches to understanding pregnancy phenotypes and birth outcomes and their links with long-term maternal and offspring health-the value of distinguishing maternal and fetal genetic effects.Frontiers in genetics · 2026Review
- Adenosine triphosphate-binding cassette transporters: key players in maintaining fetal health during pregnancy.Frontiers in endocrinology · 2026Review
- Causal effects of maternal BMI on pregnancy outcomes: a Mendelian randomisation study investigating the mediating role of blood counts.Frontiers in genetics · 2026Article
- Flexible read-aware genotype imputation from sequence using biobank sized reference panels.Nature communications · 2025Article
Corrections and comments
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Authors and funding
89 authors at 20 institutions in 10 countries.
Robin N Beaumont *Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0003-0750-8248
Christopher Flatley *Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-2225-0188
Marc Vaudel *Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.ORCID 0000-0003-1179-9578
Xiaoping WuDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Jing ChenDivision of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0002-6227-7393
Gunn-Helen MoenInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-8768-0904
Line SkotteDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0002-7398-1271
Øyvind HelgelandDepartment of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-5612-2985
Pol Solé-NavaisDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-3326-266X
Karina BanasikNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2489-2499
Clara AlbiñanaNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-3166-4120
Justiina RonkainenResearch Unit of Population Health, University of Oulu, Oulu, Finland.ORCID 0000-0001-7375-8099
João FadistaDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Sara Elizabeth StinsonNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Katerina TrajanoskaDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-3792-4296
Carol A WangSchool of Medicine and Public Health, College of Medicine, Public Health and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0002-4301-3974
David WestergaardNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0128-8432
Sundararajan SrinivasanDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.ORCID 0000-0002-3387-9889
Carlos Sánchez-SorianoCentre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK.
Jose Ramon BilbaoDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID 0000-0002-3176-501X
Catherine AllardCentre de recherche du Centre Hospitalier de l'Universite de Sherbrooke, Sherbrooke, Québec, Canada.ORCID 0000-0002-8829-4984
Marika GroleauDépartement de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.ORCID 0000-0001-6198-7724
Teemu KuulasmaaInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.ORCID 0000-0002-1795-7314
Daniel J LeirerDepartment of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
Frédérique WhiteDépartement de Biologie, Faculté des Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.ORCID 0000-0002-3442-0033
Pierre-Étienne JacquesCentre de recherche du Centre Hospitalier de l'Universite de Sherbrooke, Sherbrooke, Québec, Canada.
Haoxiang ChengIcahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID 0000-0002-1393-6006
Ke HaoIcahn School of Medicine at Mount Sinai, New York City, NY, USA.ORCID 0000-0002-1815-9197
Ole A AndreassenNORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-4461-3568
Bjørn Olav ÅsvoldK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-3837-2101
Mustafa AtalayInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Laxmi BhattaK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Luigi BouchardDepartment of Biochemistry and Functional Genomics, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Ben Michael BrumptonK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0002-3058-1059
Søren BrunakNovo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-0316-5866
Jonas Bybjerg-GrauholmDepartment for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0003-1705-4008
Cathrine EbbingDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Paul ElliottDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-7511-5684
Line EngelbrechtsenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Christian ErikstrupDepartment Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-6551-6647
Marisa EstarlichFaculty of Nursing and Chiropody, Universitat de València, C/Menendez Pelayo, Valencia, Spain.ORCID 0000-0001-9818-2663
Stephen FranksInstitute of Reproductive and Developmental Biology, Imperial College London, London, UK.
Romy GaillardThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Frank GellerDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0002-9238-3269
Jakob GroveiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID 0000-0003-2284-5744
David M HougaardDepartment for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.ORCID 0000-0001-5928-3517
Eero KajantieResearch Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, Finland.ORCID 0000-0001-7081-8391
Camilla S MorgenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Ellen A NohrInstitute of Clinical research, University of Southern Denmark, Odense, Denmark.
Mette NyegaardDepartment of Health Science and Technology, Aalborg University, Aalborg, Denmark.ORCID 0000-0003-4973-8543
Colin N A PalmerDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.ORCID 0000-0002-6415-6560
Ole Birger PedersenDepartment of Clinical Immunology, Zealand University Hospital, Køge, Denmark.ORCID 0000-0003-2312-5976
Early Growth Genetics (EGG) Consortium
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0001-9435-9441
Sylvain SebertResearch Unit of Population Health, University of Oulu, Oulu, Finland.ORCID 0000-0001-6681-6983
Beverley M ShieldsDepartment of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
Camilla StoltenbergNorwegian Institute of Public Health, Oslo, Norway.ORCID 0000-0002-8747-1985
Ida SurakkaDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.
Lise Wegner ThørnerDepartment of Clinical Immunology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Henrik UllumStatens Serum Institut, Copenhagen, Denmark.
Marja VaarasmakiResearch Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, Finland.
Bjarni J VilhjalmssonNational Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.ORCID 0000-0003-2277-9249
Cristen J WillerDepartment of Internal Medicine, Division of Cardiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5645-4966
Timo A LakkaInstitute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.ORCID 0000-0002-9199-2871
Dorte Gybel-BraskPsychotherapeutic Outpatient Clinic, Mental Health Services, Capital Region, Copenhagen, Denmark.ORCID 0000-0001-8853-4231
Mariona BustamanteSpanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-8748-3831
Ewan R PearsonDivision of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.ORCID 0000-0001-9237-8585
Rebecca M ReynoldsCentre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK.
Sisse R OstrowskiDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0001-5288-3851
Craig E PennellSchool of Medicine and Public Health, College of Medicine, Public Health and Wellbeing, The University of Newcastle, Newcastle, New South Wales, Australia.ORCID 0000-0002-0937-6165
Vincent W V JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0003-2939-0041
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID 0000-0002-9801-5774
Andrew T HattersleyDepartment of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.ORCID 0000-0001-5620-473X
Mads MelbyeK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Deborah A LawlorPopulation Health Science, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-6793-2262
Kristian HveemK.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Thomas WergeiPSYCH, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Aarhus, Denmark.ORCID 0000-0003-1829-0766
Henriette Svarre NielsenDepartment of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Denmark.ORCID 0000-0003-2106-8103
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
David M EvansFrazer Institute, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0003-0663-4621
Bo JacobssonDepartment of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-5079-2374
Marjo-Riitta JärvelinDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.ORCID 0000-0002-2149-0630
Ge ZhangDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Marie-France HivertDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.ORCID 0000-0001-7752-2585
Stefan JohanssonMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway. stefan.johansson@uib.no.ORCID 0000-0002-2298-7008
Rachel M FreathyDepartment of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. r.freathy@exeter.ac.uk.ORCID 0000-0003-4152-2238
Bjarke FeenstraDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. fee@ssi.dk.ORCID 0000-0003-1478-649X
Pål R NjølstadMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway. pal.njolstad@uib.no.ORCID 0000-0003-0304-6728
University of Copenhagen · DKStatens Serum Institut · DKErasmus MC · NLNorwegian Institute of Public Health · NONorwegian University of Science and Technology · NOUniversité de Sherbrooke · CAUniversity of Exeter · GBAarhus University · DKHaukeland University Hospital · NOUniversity of Dundee · GBUniversity of Eastern Finland · FICincinnati Children's Hospital Medical Center · USHunter Medical Research Institute · AUIcahn School of Medicine at Mount Sinai · USImperial College London · GBOulu University Hospital · FIThe University of Queensland · AUUniversity of Edinburgh · GBUniversity of Michigan · USUniversity of Oulu · FI
Funding
Placental Functional Networks Linking Developmental Pesticide Exposure and Offspring NeurodevelopmentR01ES029212 · NIEHS · EMORY UNIVERSITY · PI CAUDLE, WILLIAM MICHAEL, CHEN, JIA · 2018 to 2022
$2.7MIntegrating genomic studies of gestational duration and birth weight to understand maternal and fetal causes of adverse pregnancy outcomes and links with later diseasesR01HD101669 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI FREATHY, RACHEL, JACOBSSON, BO · 2021 to 2024
$2.1MMultidisciplinary Research Training in Asthma Genetics & GenomicsK12HL090003 · NHLBI · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2007 to 2012
$2.0MMedical Research Council G0802782Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/6Medical Research Council MR/V034294/1NICHD NIH HHS R01 HD101669NIEHS NIH HHS R01 ES029212Wellcome Trust
Abstract
A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.
Indexed as
Genome-Wide Association StudyPlacentaBirth WeightFemaleFetal DevelopmentHumansInsulinMalePregnancyInsulin
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