Evidence map›Paper›PMID 37798377›Full record

ArticleScientific reports2023

The anti-inflammatory effect of dimethyl trisulfide in experimental acute pancreatitis.

Erik Márk Orján, Eszter Sára Kormányos, Gabriella Mihalekné Fűr, Ágnes Dombi, Emese Réka Bálint, Zsolt Balla, Beáta Adél Balog, Ágnes Dágó, Ahmad Totonji, Zoárd István Bátai and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 1 country.

Erik Márk OrjánDepartment of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary.
Eszter Sára KormányosDepartment of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary.
Gabriella Mihalekné FűrDepartment of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary.
Ágnes DombiDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Emese Réka BálintDepartment of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary.
Zsolt BallaDepartment of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary.
Beáta Adél BalogDepartment of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary.
Ágnes DágóDepartment of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary.
Ahmad TotonjiDepartment of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary.
Zoárd István BátaiDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Eszter Petra JurányiDepartment of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.
Tamás DitróiDepartment of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.
Ammar Al-OmariDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Gábor PozsgaiDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Viktória KormosDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Péter NagyDepartment of Molecular Immunology and Toxicology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.
Erika PintérDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Pécs, Hungary.
Zoltán Rakonczay *Department of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary. rakonczay.zoltan@med.u-szeged.hu.
Lóránd Kiss *Department of Pathophysiology, University of Szeged, Semmelweis U. 1, 6725, Szeged, Hungary. lorand.kiss.work@gmail.com.
University of Szeged · HUUniversity of Pecs · HUNational Institute of Oncology · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Various organosulfur compounds, such as dimethyl trisulfide (DMTS), display anti-inflammatory properties. We aimed to examine the effects of DMTS on acute pancreatitis (AP) and its mechanism of action in both in vivo and in vitro studies. AP was induced in FVB/n mice or Wistar rats by caerulein, ethanol-palmitoleic acid, or L-ornithine-HCl. DMTS treatments were administered subcutaneously. AP severity was assessed by pancreatic histological scoring, pancreatic water content, and myeloperoxidase activity measurements. The behaviour of animals was followed. Pancreatic heat shock protein 72 (HSP72) expression, sulfide, and protein persulfidation were measured. In vitro acinar viability, intracellular Ca

Indexed as

PancreatitisAcute DiseaseAnimalsAnti-Inflammatory AgentsAntioxidantsCeruletideMicePancreasRatsRats, WistarSulfidesAnti-Inflammatory AgentsAntioxidantsCeruletidedimethyl trisulfideSulfides

Identifiers

PMID37798377
PMCPMC10556037
OpenAlexW4387362106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.