Evidence map›Paper›PMID 37798131›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Cognitive Aging and the Primate Basal Forebrain Revisited: Disproportionate GABAergic Vulnerability Revealed.

Cristina Bañuelos, Joshua R Kittleson, Katherine H LaNasa, Christina S Galiano, Stephanie M Roth, Evelyn J Perez, Jeffrey M Long, Mary T Roberts, Sania Fong, Peter R Rapp

Open access · hybridAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  5. Review
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  8. Article
  9. Evo-devo applied to sleep research: an approach whose time has come.Sleep advances : a journal of the Sleep Research Society · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Cristina BañuelosLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.
Joshua R KittlesonLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.
Katherine H LaNasaLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.
Christina S GalianoLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.ORCID 0000-0002-5317-2434
Stephanie M RothLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.
Evelyn J PerezLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.
Jeffrey M LongLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.
Mary T RobertsCalifornia National Primate Research Center, University of California, Davis, Davis, California 95616.
Sania FongLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224.
Peter R RappLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, Maryland 21224 rappp@mail.nih.gov.ORCID 0000-0002-0983-3944
National Institute on Aging · USUniversity of California, Davis · US

Funding

COGNITIVE FUNCTION IN THE AGED PRIMATER01AG010606 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI MORRISON, JOHN H · 1992 to 2010
$2.5M
NIA NIH HHS R01 AG010606
6 · The paper itself

Abstract

Basal forebrain (BF) projections to the hippocampus and cortex are anatomically positioned to influence a broad range of cognitive capacities that are known to decline in normal aging, including executive function and memory. Although a long history of research on neurocognitive aging has focused on the role of the cholinergic basal forebrain system, intermingled GABAergic cells are numerically as prominent and well positioned to regulate the activity of their cortical projection targets, including the hippocampus and prefrontal cortex. The effects of aging on noncholinergic BF neurons in primates, however, are largely unknown. In this study, we conducted quantitative morphometric analyses in brains from young adult (6 females, 2 males) and aged (11 females, 5 males) rhesus monkeys (

Indexed as

Basal ForebrainCognitive AgingAgingAnimalsCholinergic AgentsCholinergic NeuronsFemaleMacaca mulattaMaleCholinergic Agentsbasal forebraincholinergicE/I balanceGABAergicneurocognitive agingnonhuman primate

Identifiers

PMID37798131
PMCPMC10711728
OpenAlexW4387362739

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.